May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Relationship Between Patterns of Visual Field Loss and Scanning Laser Polarimetry–Derived Retinal Nerve Fiber Layer Measurements in the Diagnostic Innovations in Glaucoma Study (DIGS)
E.M. Hoffmann; F.A. Medeiros; P.A. Sample; R.R. A. Bourne; C. Boden; C. Bowd; L.M. Zangwill; R.N. Weinreb
Author Affiliations & Notes
  • E.M. Hoffmann
    Dept. of Ophthalmology, Hamilton Glaucoma Center, University of California of San Diego, CA
  • F.A. Medeiros
    Dept. of Ophthalmology, Hamilton Glaucoma Center, University of California of San Diego, CA
  • P.A. Sample
    Dept. of Ophthalmology, Hamilton Glaucoma Center, University of California of San Diego, CA
  • R.R. A. Bourne
    Dept. of Ophthalmology, Hamilton Glaucoma Center, University of California of San Diego, CA
  • C. Boden
    Dept. of Ophthalmology, Hamilton Glaucoma Center, University of California of San Diego, CA
  • C. Bowd
    Dept. of Ophthalmology, Hamilton Glaucoma Center, University of California of San Diego, CA
  • L.M. Zangwill
    Dept. of Ophthalmology, Hamilton Glaucoma Center, University of California of San Diego, CA
  • R.N. Weinreb
    Dept. of Ophthalmology, Hamilton Glaucoma Center, University of California of San Diego, CA
  • Footnotes
    Commercial Relationships  E.M. Hoffmann, None; F.A. Medeiros, None; P.A. Sample, Carl Zeiss Meditec F; R.R.A. Bourne, None; C. Boden, None; C. Bowd, None; L.M. Zangwill, Carl Zeiss Meditec F; R.N. Weinreb, Carl Zeiss Meditec F; Laser Diagnostic Technologies, LDT F; Heidelberg Engineering F.
  • Footnotes
    Support  Ho 3277/1–1 DFG Grant (EMH); NIH Grants EY08208 (PAS), EY11008(LMZ); TFC Frost (RRAB)
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 2480. doi:
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      E.M. Hoffmann, F.A. Medeiros, P.A. Sample, R.R. A. Bourne, C. Boden, C. Bowd, L.M. Zangwill, R.N. Weinreb; Relationship Between Patterns of Visual Field Loss and Scanning Laser Polarimetry–Derived Retinal Nerve Fiber Layer Measurements in the Diagnostic Innovations in Glaucoma Study (DIGS) . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2480.

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Abstract

Abstract: : Purpose: To investigate the association between patterns of visual field (VF) loss and retinal nerve fiber layer (RNFL) thickness measurements obtained with scanning laser polarimetry (GDX VCC). Methods: 121 glaucoma patients and 65 normal controls were included. (Mean age 67.0 years±12.0 years and 65.0 years± 8.7 years, respectively). All glaucoma patients had repeatable abnormal VFs using standard automated perimetry (SAP SITA) and GDx VCC imaging within six months. GDx VCC RNFL thickness measurements were obtained from 16 equal parapapillary sectors. Patterns of VF loss were classified as arcuate, partial arcuate, nasal step, or paracentral in each VF hemifield. Logistic regression analysis was performed to determine which RNFL sectors were associated with each VF pattern. The ability of GDx VCC to discriminate between patients with different VF patterns and normal controls using ROC curve analyses was also investigated. Results:Arcuate (n=29), partial arcuate (n=29) nasal step (n=17), and paracentral (n=18) VF patterns in the superior hemifield were significantly associated with RNFL sectors in the temporal and temporal–inferior hemiretina (P < 0.001). ROC curve areas for discrimination between patients with patterns of VF loss and normal controls ranged from 0.85 to 0.95. VF patterns in the inferior hemifield (Arcuate, n=12, partial arcuate, n=15, nasal step, n=30, paracentral, n=17) were most strongly associated with temporal and temporal–superior RNFL sectors (P = 0.02). ROC curve areas for discrimination between different patterns of VF loss and normal controls ranged from 0.73 to 0.98. Furthermore, GDx VCC could discriminate between normal VF hemifields in glaucoma patients and VF hemifields in normal controls (ROC curve area = 0.81 superior VF hemifield, 0.73 inferior VF hemifield). Conclusions: The RNFL in the specific sectors of the parapapillary retina was topographically related to patterns of visual field loss. GDx VCC can differentiate between apparently normal VF hemifields in glaucoma patients and VF hemifields in normal controls.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • perimetry • nerve fiber layer 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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