May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Assessing Glaucomatous Progression Using Longitudinal Scanning Laser Tomography (HRTII) Measurements in the Glaucoma Imaging Longitudinal Study
Author Affiliations & Notes
  • H.D. Jampel
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD
  • Y. Ding
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD
  • H. Quigley
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD
  • C. Marks
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD
  • F. Knezevich
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD
  • D. Friedman
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD
  • N. Congdon
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD
  • S. Vitale
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD
    Division of Epidemiology and Clinical Research, National Eye Institute, National Institutes of Health, Bethesda, MD
  • R. Zeimer
    Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD
  • Footnotes
    Commercial Relationships  H.D. Jampel, None; Y. Ding, None; H. Quigley, None; C. Marks, None; F. Knezevich, None; D. Friedman, None; N. Congdon, None; S. Vitale, None; R. Zeimer, Talia Technology, Ltd. P.
  • Footnotes
    Support  NEI R01 12295
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 2530. doi:
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    • Get Citation

      H.D. Jampel, Y. Ding, H. Quigley, C. Marks, F. Knezevich, D. Friedman, N. Congdon, S. Vitale, R. Zeimer; Assessing Glaucomatous Progression Using Longitudinal Scanning Laser Tomography (HRTII) Measurements in the Glaucoma Imaging Longitudinal Study . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2530.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Abstract:
 

To assess progression of optic disc damage by scanninglaser tomography (HRT II) in glaucoma patients participatingin the Glaucoma Imaging Longitudinal Study (GILS).

 

The GILS follows 205 glaucoma patients every 6 months.We analyzed optic disc and retinal nerve fiber layer measurementsfor GILS participants with at least 3 HRT II images. Progressionwas assessed by two methods: 1) linear regression analysis,with progression defined as a significant slope of rim area(RA), cup volume (CV), cup shape measure (CSM), or mean RNFLthickness (RNFL); and 2) change in the sectoral Moorfields regressionanalysis from normal to outside normal limits on two consecutivedates.

 

Images from 243 eyes of 164 subjects were analyzedwith mean follow up of 20 months.

 

Yearly progression rate defined by statistically significantslope  

Yearly progression rate defined by repeatable change in Moorfieldsregression analysis:

 

 

(WNL=within normal limits; ONL=outside normal limits; BRDLN=borderline;Temp=temporal; Nas=nasal; Inf=inferior; Sup=superior)

 

Estimates of progression rates using HRT summaryparameters were consistent with other longitudinal studies ofglaucoma patients. Progression rates by linear regression werehigher than those byMoorfields regression analysis. Sectoralchanges using Moorfields regression were similar in magnitude,but tended to be higher for superiorly than inferiorly.

 

 
Keywords: optic disc • imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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