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H.D. Jampel, Y. Ding, H. Quigley, C. Marks, F. Knezevich, D. Friedman, N. Congdon, S. Vitale, R. Zeimer; Assessing Glaucomatous Progression Using Longitudinal Scanning Laser Tomography (HRTII) Measurements in the Glaucoma Imaging Longitudinal Study . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2530.
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To assess progression of optic disc damage by scanninglaser tomography (HRT II) in glaucoma patients participatingin the Glaucoma Imaging Longitudinal Study (GILS).
The GILS follows 205 glaucoma patients every 6 months.We analyzed optic disc and retinal nerve fiber layer measurementsfor GILS participants with at least 3 HRT II images. Progressionwas assessed by two methods: 1) linear regression analysis,with progression defined as a significant slope of rim area(RA), cup volume (CV), cup shape measure (CSM), or mean RNFLthickness (RNFL); and 2) change in the sectoral Moorfields regressionanalysis from normal to outside normal limits on two consecutivedates.
Images from 243 eyes of 164 subjects were analyzedwith mean follow up of 20 months.
Yearly progression rate defined by statistically significantslope
Estimates of progression rates using HRT summaryparameters were consistent with other longitudinal studies ofglaucoma patients. Progression rates by linear regression werehigher than those byMoorfields regression analysis. Sectoralchanges using Moorfields regression were similar in magnitude,but tended to be higher for superiorly than inferiorly.
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