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E.Z. Blumenthal, A. Horani, R. Sasikumar, G.C. Sekhar, A. Udaykumar, R. Thomas; Correlating Structure With Function in End–stage Glaucoma . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2536.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To correlate structure and function in end–stage glaucoma eyes, using scanning laser polarimetry (SLP) as a measure of structure, and standard achromatic perimetry (SAP) as a measure of the functional status of the eye. Methods: Fifty–six eyes of 48 glaucoma patients presenting with end–stage glaucoma, as defined by both a glaucomatous optic disc with a vertical cup–to–disk (C/D) ratio of >0.9, and a SAP visual field (VF) criteria (mean deviation (MD) worse than –20dB) underwent SLP imaging using the GDX VCC unit. Patients were recruited at two tertiary referral centers: Hadassah Hospital, Jerusalem, and L.V. Prasad Eye Institute, Hyderabad. Results: The VF MD was: –26.75 ± 3.50. The remaining RNFL layer, as measured using SLP, in this group of eyes was: TSNIT Average: 29.76 ± 5.81; Superior Average: 30.76 ± 6.25; Inferior Average: 31.14 ± 7.20. Poor structure–function correlation was found when analyzing separately the superior and the inferior hemifields (r2=0.003, r2=0.04, respectively). Conclusions: In eyes with end–stage glaucoma little remaining RNFL is found with scanning laser polarimetry, however, these values rarely drop below 10–20 microns. A flattening of the GDx TSNIT pattern is evident, and the correlation between structure and function is mostly lost.
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