Correlations of Retinal Light Sensitivity for Retinal Nerve Fiber Layer Thickness Measured by GDx–VCC or Optical Coherence Tomography and Optic Disc Configuration by Heidelberg Retina Tomograph

Abstract

Abstract: : Purpose: To evaluate the relationships among retinal light sensitivity (RLS) and optic disc parameters by Heidelberg Retina Tomograph (HRT) or retinal nerve fiber layer thickness (RNFLT) measured by GDx–VCC or Optical Coherence Tomography (OCT). MEHODS: One hundred nineteen, randomly selected eyes with open angle glaucoma (OAG) and 80 normal eyes were examined with HRT, GDx–VCC and OCT. RLS was recorded in the dB and the 1/Lambert (1/L) scales by Humphrey Field Analyzer. The correlations among RLS and global parameters by the 3 instruments were determined both in OAG eyes and OAG+normal eyes. Furthermore, multiple regression analysis in a stepwise forward approach was used for the correlations among the RLS and these structural parameters in both groups. Results: Most structural parameters showed quadratic rather than linear correlations with RLS in the dB scale. Linear correlations were found between most parameters and RLS in the 1/L scales in OAG eyes (average RNFLT by OCT:0.493, NFI by GDx–VCC: 0.561, rim area by HRT: 0318) and in OAG+normal eyes (average RNFLT by OCT:0.754, NFI by GDx–VCC: 0.764, rim area by HRT: 0.464). Multiple regression models improved the correlation coefficients (r = 0.610 in OAG group and 0.814 in all eyes group) for the 1/L–RLS. CONCLUSIONS: Optic disc analysis by HRT and RNFLT measurement by GDx–VCC and OCT relates quadratically with dB scale and lineally with 1/L scale of RLS both in OAG eyes and OAG+ normal eyes. Complement examination of the 3 instruments may be useful for evaluation of glaucoma.

Keywords: imaging/image analysis: clinical • nerve fiber layer • optic disc