May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Structure–Function Relationships in Glaucoma Eyes Using New–Generation CSLO, OCT and SLP Imaging in the Diagnostic Innovations in Glaucoma Study (DIGS)
Author Affiliations & Notes
  • C. Bowd
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, CA
  • E.M. Hoffmann
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, CA
  • F.A. Medeiros
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, CA
  • R.R. A. Bourne
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, CA
  • R.N. Weinreb
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, CA
  • P.A. Sample
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, CA
  • L.M. Zangwill
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California, San Diego, La Jolla, CA
  • Footnotes
    Commercial Relationships  C. Bowd, None; E.M. Hoffmann, Heidelberg Engineering F; F.A. Medeiros, None; R.R.A. Bourne, Heidelberg Engineering F; R.N. Weinreb, Heidelberg Engineering F; Carl Zeiss Meditec F; Laser Diagnostic Technologies F; P.A. Sample, Carl Zeiss Meditec F; L.M. Zangwill, Heidelberg Engineering F; Carl Zeiss Meditec F; Laser Diagnostic Technologies F.
  • Footnotes
    Support  DFG Germany, TFC Frost UK, NIH Grant EY08208, NIH Grant EY11008
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 2544. doi:
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      C. Bowd, E.M. Hoffmann, F.A. Medeiros, R.R. A. Bourne, R.N. Weinreb, P.A. Sample, L.M. Zangwill; Structure–Function Relationships in Glaucoma Eyes Using New–Generation CSLO, OCT and SLP Imaging in the Diagnostic Innovations in Glaucoma Study (DIGS) . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2544.

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Abstract
 
Abstract:
 

To assess the strength of the association between visual field (VF) sensitivity and RNFL thickness/optic disc topography measured using HRT II, StratusOCT and GDx VCC, in glaucoma eyes.

 

62 eyes from 62 glaucoma patients were tested on standard automated perimetry (SAP SITA), HRT II, StratusOCT, and GDx VCC within three months of each other. Inclusion criterion was a repeatable (2 consecutive) abnormal SAP result (GHT outside of normal limits and/or PSD with p < 5%) with a repeatable pattern of defect. Linear associations between SAP sensitivity (dB and 1/L scales) and RNFL thickness (HRT II, StratusOCT and GDx VCC) and retinal height along the optic disc margin (mean height contour, MHC, HRT II) were determined globally and for 6 VF regions (superior, superior nasal, nasal, inferior nasal, inferior, temporal) and 6 corresponding RNFL/optic disc sectors (inferior, inferior temporal, temporal, superior temporal, superior, nasal).

 

Average SAP MD was –6.0 dB (SD = 5.2 dB). The associations (R2) between global and regional VF sensitivity (dB, 1/L) and RNFL/optic disc measurements are shown below.

 

Structure–function relationships were strongest locally between the inferior nasal VF and the superior temporal RNFL/optic disc sector. This association was strongest for StratusOCT, followed by HRT II RNFL thickness and HRT II MHC. Global associations were strongest for StratusOCT, followed by HRT II RNFL thickness and HRT II MHC. Linear associations between imaging measurements and VF sensitivity were generally stronger when sensitivity was expressed in dB scale. StratusOCT measured RNFL thickness was the best indicator of SAP sensitivity in our sample.

 

 

 
Keywords: imaging/image analysis: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • visual fields 
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