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C. Bowd, E.M. Hoffmann, F.A. Medeiros, R.R. A. Bourne, R.N. Weinreb, P.A. Sample, L.M. Zangwill; Structure–Function Relationships in Glaucoma Eyes Using New–Generation CSLO, OCT and SLP Imaging in the Diagnostic Innovations in Glaucoma Study (DIGS) . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2544.
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© ARVO (1962-2015); The Authors (2016-present)
To assess the strength of the association between visual field (VF) sensitivity and RNFL thickness/optic disc topography measured using HRT II, StratusOCT and GDx VCC, in glaucoma eyes.
62 eyes from 62 glaucoma patients were tested on standard automated perimetry (SAP SITA), HRT II, StratusOCT, and GDx VCC within three months of each other. Inclusion criterion was a repeatable (2 consecutive) abnormal SAP result (GHT outside of normal limits and/or PSD with p < 5%) with a repeatable pattern of defect. Linear associations between SAP sensitivity (dB and 1/L scales) and RNFL thickness (HRT II, StratusOCT and GDx VCC) and retinal height along the optic disc margin (mean height contour, MHC, HRT II) were determined globally and for 6 VF regions (superior, superior nasal, nasal, inferior nasal, inferior, temporal) and 6 corresponding RNFL/optic disc sectors (inferior, inferior temporal, temporal, superior temporal, superior, nasal).
Average SAP MD was –6.0 dB (SD = 5.2 dB). The associations (R2) between global and regional VF sensitivity (dB, 1/L) and RNFL/optic disc measurements are shown below.
Structure–function relationships were strongest locally between the inferior nasal VF and the superior temporal RNFL/optic disc sector. This association was strongest for StratusOCT, followed by HRT II RNFL thickness and HRT II MHC. Global associations were strongest for StratusOCT, followed by HRT II RNFL thickness and HRT II MHC. Linear associations between imaging measurements and VF sensitivity were generally stronger when sensitivity was expressed in dB scale. StratusOCT measured RNFL thickness was the best indicator of SAP sensitivity in our sample.
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