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M.D. Wojtkowski, V.J. Srinivasan, T.H. Ko, A.J. Witkin, A.H. Rogers, C.R. Baumal, E. Reichel, J.S. Schuman, J.S. Duker, J.G. Fujimoto; Improved Visualization of Retinal Pathologies Using High–Speed, Ultrahigh Resolution OCT . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2565.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To demonstrate the capability of high–speed, ultrahigh resolution optical coherence tomography to improve visualization of architectural morphology in retinal diseases. To identify retinal pathologies where this novel technique yields information on architectural morphology that is not available with standard OCT imaging. To present new scanning protocols for retinal imaging. Methods: New high–speed, ultrahigh resolution OCT technology based on "spectral/Fourier domain" detection has been developed which enables imaging with ∼3 um axial image resolution, 60 times faster than commercial StratusOCT instruments. The high scan speeds enable improved visualization of intraretinal layers and improved coverage of the retina. A set of new scanning protocols is designed to provide both high quality cross–sectional images and OCT three–dimensional data with sufficient coverage for mapping. High–speed, ultrahigh resolution OCT and standard resolution StratusOCT imaging are performed in the same patients and results are correlated with standard ophthalmoscopic clinical examination. Results: High–speed, ultrahigh resolution OCT imaging has been performed in more than 110 eyes of 70 patients with various retinal diseases. A cross–section of retinal pathologies including macular holes, macular edema, diabetic retinopathy, age–related macular degeneration, epiretinal membrane, central serous chorioretinopathy has been surveyed. Compared to commercial StratusOCT and the standard ultrahigh resolution OCT, this new technology enables better visualization of intraretinal architectural morphology. High–speed, ultrahigh resolution OCT enables the detection and analysis of small, focal pathologic changes which can be missed in standard OCT imaging. These investigations also provide a baseline for interpreting intraretinal features seen with standard resolution OCT. Conclusions: High–speed, ultrahigh resolution OCT enables significantly better visualization of changes in intraretinal morphology than previously possible. Small pathologic changes in the photoreceptors and retinal pigment epithelium can be visualized. The 60x improvement in imaging speed combined with ultrahigh resolution promises to enable a wide range of new clinical ophthalmic imaging applications.
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