Abstract
Abstract: :
Purpose: To compare optical coherence tomography (OCT) with fluorescein angiography (FA) for the assessment of cystoid macular edema (CMD) in patients with uveitis (2) To investigate the correlation between tomographic feature and visual acuity. Methods: This is a cross–sectional study between February and November 2004. Patients followed for uveitis with macular edema and adequate media clarity underwent OCT and FA at the same time. Results: One hundred and twenty nine eyes of 90 patients of varied causes were included. Mean duration of uveitis was 39 months. Four patients had anterior uveitis (4.4%), 10 patients had intermediate uveitis (11.1%), 15 patients had panuveitis (16.7%) and 61 patients had posterior uveitis (67.8%). Mean visual acuity was 0.5 (logMAR). Mean retinal thickness at the central fovea was 357±128µm. One hundred and eleven eyes had similar results on both OCT and FA (86%). In 9 eyes, subretinal fluid was detected on OCT but not FA (7%). Nine eyes had CME on FA but not OCT (7%). There were 3 patterns of macular edema: diffuse macular edema (DME), cystoid macular edema (CME) and serous retinal detachment (SRD). DME was detected in 45 eyes (34.9%) and in 8 (6.2%) of these eyes, DME was associated with SRD. CME was found in 61 eyes (47.2%) and in 18 of these eyes (14%), CME was associated with SRD. Epiretinal membrane (ERM) was detected by OCT in 27 eyes (21%). Six eyes demonstrated vitreomacular traction (4.7%). Retinal thickness measurements was significantly greater in eyes with SRD than eyes without SRD (p<0.005) and in eyes with CME than eyes with DME (p<0.0005). There was no significant difference of retinal thickness measurements in eyes with and without ERM. There was no significant difference of visual acuity in eyes with and without RD. There was a poor correlation between logarithmic visual acuity and retinal thickness (R2 = 0.19). Conclusions: OCT is effective in detection of macular edema. It allows determination of the distribution of fluid and quantification of retinal thickness. However, it does not supplant the use of FA.
Keywords: uveitis-clinical/animal model • imaging/image analysis: clinical • macula/fovea