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I. Maruko, T. Iida, S. Kishi, R.F. Spaid; Indocyanine Green Angiography Abnormality of the Periphery in Best's Disease . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2586.
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Purpose: To report patients with Best’s disease (vitelliform macular dystrophy) and multifocal Best’s disease who had peripheral abnormalities seen only with indocyanine green angiography. Methods: Four eyes of 2 patients (13–year–old girls, twin) who had only central macular lesion and 4 eyes of 2 patients (53–year–old woman, 56–year–old man) who had multifocal lesion were studied. Results of indocyanine green angiography were compared with finding on ophthalmoscopy and fluorescein angiography. Results: Throughout the fundus periphery indocyanine green angiography demonstrated multiple hyperfluorescent spots. Most of the spots were observed in the mid–periphery and the periphery even in the area with no observable abnormality by ophthalmoscopy or fluorescein angiography. Conclusions: The widespread nature of hyperfluorescent spots is consistent with the known histopathology, which also shows wide–ranging abnormalities of the retinal pigment epithelium, Bruch’s membrane and the choroids. uorescein angiography.
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