May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Archipelago Keratitis: A Herpes Mediated Epithelial Cell Activation Syndrome?
T. Hoang–Xuan; N. Alfonsi; L. Racine; G. Sultan; C. Baudouin; E.E. Gabison
Author Affiliations & Notes
  • T. Hoang–Xuan
    Ophthalmology, Fondation Rothschild, Paris, France
  • N. Alfonsi
    Ophthalmology, Fondation Rothschild, Paris, France
  • L. Racine
    Ophthalmology, Fondation Rothschild, Paris, France
  • G. Sultan
    Ophthalmology, CHNO des XV/XX, Paris, France
  • C. Baudouin
    Ophthalmology, CHNO des XV/XX, Paris, France
  • E.E. Gabison
    Ophthalmology, Fondation Rothschild, Paris, France
  • Footnotes
    Commercial Relationships  T. Hoang–Xuan, None; N. Alfonsi, None; L. Racine, None; G. Sultan, None; C. Baudouin, None; E.E. Gabison, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 2619. doi:
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      T. Hoang–Xuan, N. Alfonsi, L. Racine, G. Sultan, C. Baudouin, E.E. Gabison; Archipelago Keratitis: A Herpes Mediated Epithelial Cell Activation Syndrome? . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2619.

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Abstract

Abstract: : Purpose: To report 5 cases of Archipelago keratitis, a distinct entity of herpetic epithelial keratitis and to propose a hypothesis regarding the physiopathogenesis of this syndrome. Methods: Case report with clinical examination, corneal scraping for Herpes PCR and in vivo HRT2 confocal microscopy.Results: We describe a form of herpetic keratitis consisting of a limbal infiltrate associated with epithelial erosions which have a linear centripetal disposition. All the patients had a past history of herpetic keratitis. The evolution over 3 weeks was marked by the appearance of nummular subepithelial opacities. Corneal scraping performed in 3 cases revealed positive PCR for herpes simplex in two cases (HSV1, HSV2). Confocal in vivo microscopy (HRT2 with corneal unit ) revealed the presence of ballooned epithelial cells and subepithelial infiltrates of inflammatory cells. All the patients healed with oral valacyclovir treatment.Conclusions:We believe that during the evolution of a limbal recurrence of herpetic disease, inflammatory mediators may in some cases promote the migration of limbal epithelial cells towards the center of the cornea, hence facilitating the dissemination of the viral infection.

Keywords: keratitis • herpes simplex virus • cornea: clinical science 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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