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N. Yepes, A.R. Slomovic, D. Rootman; Corneal Re–Epithelialization After Postoperative Use of Moxifloxacin 0.5% in Penetrating Keratoplasty . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2705.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To evaluate corneal re–epithelialization after use of Moxifloxacin 0.5% and Prednisolone Acetate 1% drops in patients who have undergone corneal transplantation. Methods: This was a prospective study on 20 consecutive eyes of 20 patients undergoing elective penetrating keratoplasty. Patients were instructed to use Moxifloxacin 0.5% (Vigamox, Alcon Fort Wort, Texas) tid and Prednisolone acetate 1%( Pred Forte, Allergan Inc) qid; starting on the first postoperative day and continuing until the donor tissue was totally re–epithelialized. Area measurements of the corneal epithelial defect were performed using digital photographs after fluorescein staining of the ocular surface. If the epithelial defect was still present at the seventh day, measurements were taken every two days thereafter. Area of the defect was analyzed using the Image J program (Scion Corporation). Results: The average area of the epithelial defect on the first postoperative day was 24mm2+/– 14.6, 5.8 mm2+/– 6.6 on day three, 0.9 mm2+/– 3.2 on day seven, and 0.3mm2 +/– 1.1 on day nine. The average time to corneal re–epithelialization was 6 days (range 3 to11 days). Seven of the twenty donor corneas (35%), were totally re–epithelialized by day three and seventeen of the donor corneas (85%), were totally re–epithelialized at the end of the first week. All donor corneas were totally re–epithelialized by day eleven. Conclusions: Vigamox did not delay normal corneal re–epithelialization after corneal transplantation compared to previous studies.
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