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K. Masuzawa, T. Hiraoka, Y. Kaji, T. Wakabayashi, P.N. Nanbu, F. Okamoto, T. Oshika; Comparison of Micafungin and Fluconazole for Experimental Candida Keratitis in Rabbits . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2778.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To evaluate the efficacy of subconjunctival injection of 0.1% micafungin and 0.2% fluconazole in the treatment of experimental Candida albicans keratitis in rabbits. Methods: In 24 New Zealand white rabbits, Candida albicans (5×104 yeast cells) was inoculated in the corneal stroma of right eye. The animals were randomly assigned to three groups and received subconjunctival injection of 0.5 ml of 0.1% micafungin, 0.2% fluconazole, or physiologic saline once a day for three weeks. The eyes were examined slit–lamp biomicroscopically and histopathologically. Clinical course of fungal keratitis was compared between three groups. Results: The clinical scores were significantly lower in the micafungin group than the other two groups throughout the study period (P<0.0001 ∼ P=0.0027, Bonferroni’s multiple comparison test). The fluconazole group showed significantly lower clinical scores than the saline group on day 18 (P=0.0343). At the end of the study period, there were significant differences between the saline and the micafungin groups (P<0.0001), the saline and the fluconazole groups (P=0.0072), and the fluconazole and the micafungin groups (P=0.0013). Histopathologically, similar results were obtained. Subconjunctival injection of 0.1% micafungin was well tolerated and no adverse effects were observed. Conclusions: Subconjunctival administration of micafungin was effective in the treatment of experimental Candida keratitis. Topical application of micafungin would be a feasible treatment option for clinical fungal keratitis.
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