May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Interaction of B7–H1/PD–1 in Herpetic Stromal Keratitis
J. Her; H.–Y. Sohn; J.–H. Kim; I.–H. Choi
Author Affiliations & Notes
  • J. Her
    Ophthalmology,
    Inje University Paik Hospital, Busan, Republic of Korea
  • H.–Y. Sohn
    Yang San Eye Clinic, Yangsan, Republic of Korea
  • J.–H. Kim
    Good Morning–St. Mary Eye Clinic, Busan, Republic of Korea
  • I.–H. Choi
    Microbiology,
    Inje University Paik Hospital, Busan, Republic of Korea
  • Footnotes
    Commercial Relationships  J. Her, None; H. Sohn, None; J. Kim, None; I. Choi, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 2796. doi:
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      J. Her, H.–Y. Sohn, J.–H. Kim, I.–H. Choi; Interaction of B7–H1/PD–1 in Herpetic Stromal Keratitis . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2796.

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Abstract

Abstract: : Purpose: Interaction of programmed death–1(PD–1) and its ligand 1(PD–L1; B7–H1) has been implicated in the regulation of effector T cell. The role of interaction of B7–H1 and PD–1 was studied in herpetic stromal keratitis. Methods: B7–H1 and PD–1 expression was examined in the cells of cervical lymph node by a flow cytometry on day 0,5,7, and 12, after infection. 200ug of anti–mouse B7–H1 were injected intraperitoneally 1 day before and 2 days after infection. HSV–1–specific CD4 T cell activity was determined by flow cytometry and ELISA. Results: More than 50% of T cells infiltrating the cornea were B7–H1 and PD–1 cells. Stromal keratits got significantly worse after administration of antibody compared with the control. Conclusions: PD–1 and B7–H1 might play an important role in maintanining immunologic tolerance of the cornea and their interaction might be implicated in the pathogenesis of HSK.

Keywords: herpes simplex virus • immune tolerance/privilege • cornea: clinical science 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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