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J. Her, H.–Y. Sohn, J.–H. Kim, I.–H. Choi; Interaction of B7–H1/PD–1 in Herpetic Stromal Keratitis . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2796.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Interaction of programmed death–1(PD–1) and its ligand 1(PD–L1; B7–H1) has been implicated in the regulation of effector T cell. The role of interaction of B7–H1 and PD–1 was studied in herpetic stromal keratitis. Methods: B7–H1 and PD–1 expression was examined in the cells of cervical lymph node by a flow cytometry on day 0,5,7, and 12, after infection. 200ug of anti–mouse B7–H1 were injected intraperitoneally 1 day before and 2 days after infection. HSV–1–specific CD4 T cell activity was determined by flow cytometry and ELISA. Results: More than 50% of T cells infiltrating the cornea were B7–H1 and PD–1 cells. Stromal keratits got significantly worse after administration of antibody compared with the control. Conclusions: PD–1 and B7–H1 might play an important role in maintanining immunologic tolerance of the cornea and their interaction might be implicated in the pathogenesis of HSK.
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