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J.E. Coffman, J.R. Smith, E.B. Suhler, N.K. Wade, J.D. Reveille, L. Diekman, M. Weisman, D.T. Y. Yu, J.T. Rosenbaum, T.M. Martin; The Accuracy of Self–Reporting Acute Anterior Uveitis . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2845.
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To measure the accuracy of self–reporting acute anterior uveitis (AAU), i.e. the phenotype of uveitis associated with the HLA–B27–positive spondyloarthropathies.
Participants who reported a diagnosis of uveitis consistent with AAU at screening were enrolled by informed consent into the study of genetic susceptibility to AAU. Participants were divided into four groups: those who contacted us independently, seen in the Casey Eye Institute (CEI) uveitis clinic, referred by a collaborating ophthalmologist or rheumatologist, or referred by the Spondylitis Association of America (SAA). Ophthalmology records were reviewed by one uveitis specialist (JRS) to confirm AAU (i.e., sudden onset, anterior and multiple unilateral attacks <12 weeks duration). Resultant chart reviews were grouped as follows: confirmed AAU; no AAU; inconclusive medical records; and probable AAU with only a single episode documented.
176 participants (97 females and 79 males; ages 13–84, mean 48.5) were evaluated by chart review. AAU was confirmed in 145 (82.4%) participants, while 20 (11.4%) had no AAU. There were 6 and 5 cases of inconclusive and single episodes of AAU, respectively. The table illustrates each participant group. A Chi–square test was performed with 3 degrees of freedom (P=0.410).
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