Purchase this article with an account.
N. Kawaguchi, D. Kurosaka, M. Yoshino, K. Nakamura, K. Negishi, K. Tsubota; The Inhibitory Effect of Optic Edge of Intraocular Lens on Lens Epithelial Cell Migration Is Not Dependent on Optic Material . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2855.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: To reveal the factors which influence the inhibitory effect of optic edge of intraocular lens (IOL) on migration of lens epithelial cells (LECs). Methods: Porcine LECs were cultured in a cell culture chamber insert, containing a collagen membrane, with IOL optics fixed by the various stainless weights (33, 55, and 110 mg). The employed IOLs were AMO Senser AR40, AMO Senser OptiEdge AR40e, and AMO ClariFlex. The AR40 is almost the same design and material as AR40e except design of optic edge (the optic edge of AR40 is rounded and one of AR40e is sharp). ClariFlex is the same design as AR40e, but optic of ClariFlex is made of silicone, and one of AR40e is of acrylic. Forty–eight hours after culture, to examine the extent of blocking of LEC migration by the edges of the various IOL optics, we measured and summed the angles at the center of the optic that subtended margin portions where LECs had not migrated at removal of IOL optic and stainless weight. The ratio of the sum of these angles to the angle of the entire circumference (360°) was taken as a measure of blocking ability. Results: The blocking abilities of AR40 were 80.8 ± 5.2% (pressed by 33mg), 77.2 ± 9.1% (pressed by 55mg), and 43.1 ± 4.4% (pressed by 110mg). The blocking abilities of AR40e were 75.1 ± 14.4%, 65.72 ± 9.6%, and 22.2 ± 10.8%, respectively. The blocking abilities of ClariFlex were 68.8 ± 16.5%, 62.3 ± 9.9%, and 17.6 ±3.1%, respectively. The blocking ability was affected by the type of the IOL (p=0.0001) and the weight of the stainless weight (p<0.0001). The blocking abilities of AR40e and ClariFlex were significantly higher than that of AR40 (p=0.0015, p<0.0001, respectively). There was no difference in the blocking ability between AR40e and ClariFlex (p=0.2056). The heavier weight blocked more effectively LEC migration regardless of shape of optic edge and material (p<0.0001). Conclusions: These findings suggested that the blocking ability of IOL optic is dependent on the shape of the edge and the pressure between collagen membrane and optic edge, but not on the optic material.
This PDF is available to Subscribers Only