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W. Wee, H. Lee, M. Kim, J. Ko, H.J. Lee, J. Lee; Effect of Poly Ethylene Glycol Polymerization to the Acrylic Intraoucular Lens on the Prevention of Posterior Capsular Opacification . Invest. Ophthalmol. Vis. Sci. 2005;46(13):2856.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To investigate the effect of poly ethylene glycol(PEG) grafted acryl intraocular lenses (IOL) on the prevention of posterior capsular opacification(PCO). Methods: The acrylic surface of IOL (AcrylsofR SA 60AT, Alcon) was polymerized with PEG. To investigate cell adhesion on the modified lens surface, rabbit lens epithelial cells (2x103 cells/ml) were inoculated on each PEG grafted lenses and control acryl lenses, and were cultured in a carbon dioxide incubator for 24 hours. The adhered cells were trypsinized and were counted. The PEG grafted IOL were implanted in 5 New Zealand rabbits after phacoemulsification. The formations of PCO were checked serially through retroilluminated digital photographies and the severity scores were calculated using software named POCOman (St. Thomas hospital and King’s college, UK). The cell adherence pattern on the PEG grafted IOL was examined by scanning electron microscopy (JSM–300, Jeol, Japan). Results: The mean number of adhered cells was much smaller than that of unmodified acrylic control. The mean severities of post capsular opacification were 0.13, 0.44, and 1.08 in PEG–grafted IOL and 0.13, 0.71, and 1.64 in control acryl at 1, 4, 8 week, respectively. The formation of PCO in PEG–IOL tended to be lower compared with that in control. Scanning electron microscopy showed that small round cells were more sparsely scattered on the PEG–grafted acrylic lens in contrast to the control. Conclusions: PEG grafting to the acrylic IOL may lessen the formation of posterior capsular opacification.
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