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I. Kawasaki, S. Yoneya, N. Takata, P.L. Gehlbach, T. Awata, K. Mori; Vascular Endothelial Growth Factor Gene C–634G Polymorphism Is Associated With Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3002.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To examine the potential relationship of vascular endothelial growth factor (VEGF) gene polymorphisms and development of age–related macular degeneration (AMD) in a native Japanese population. Methods: Sixty–five patients with AMD and 96 control subjects without AMD were recruited for this study. All were unrelated Japanese individuals. Genomic DNA was extracted from peripheral blood of each individual. Two polymorphisms of VEGF gene; the C–634G and the C–2578A were analyzed using ABI prism 7000. Results: The CC, CG and GG genotypes of C–634G in AMD patients were 12.3%, 63.1% and 24.6%, respectively. In control individuals, The CC, CG and GG genotypes of C–634G were 22.9%, 43.8% and 33.3%, respectively. Genotype distribution of the C–634G polymorphism of VEGF gene was significantly different between AMD patients and control subjects (p =0.047), but that of the C–2578A polymorphism was not (p =0.074). Conclusions: These preliminary results suggest that the VEGF gene polymorphism may represent a possible genetic risk factor for AMD in the Japanese population, encouraging further recruitment of patients and control subjects.
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