May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
The Association of Wnt9/14 With Chick Retina Development
Author Affiliations & Notes
  • M. Suzuki
    Department of Ophthalmology, Hiroshima University, Hiroshima, Japan
  • T. Kanamoto
    Department of Ophthalmology, Hiroshima University, Hiroshima, Japan
  • S. Tanimoto
    Department of Ophthalmology, Hiroshima University, Hiroshima, Japan
  • H. Tamura
    Department of Ophthalmology, Hiroshima University, Hiroshima, Japan
  • H. Okumichi
    Department of Ophthalmology, Hiroshima University, Hiroshima, Japan
  • H.K. Mishima
    Department of Ophthalmology, Hiroshima University, Hiroshima, Japan
  • Footnotes
    Commercial Relationships  M. Suzuki, None; T. Kanamoto, None; S. Tanimoto, None; H. Tamura, None; H. Okumichi, None; H.K. Mishima, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 3124. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      M. Suzuki, T. Kanamoto, S. Tanimoto, H. Tamura, H. Okumichi, H.K. Mishima; The Association of Wnt9/14 With Chick Retina Development . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3124.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: To investigate the molecular and biological function of Wnt 9/14 in chick retina development. Methods: Proteomics analysis of chick embryo retina, embryonic day7(E7) and day11(E11), were performed, and the up–regurated proteins, including Wnt 9/14, were identified by mass–spectrometry. The change of Wnt 9/14 expressions were examined using Western blot analysis. Immunohistochemical procedure were performed to examine the localization of the proteins. Results: Wnt 9/14 was more highly expressed in matured stage(E11) than pre–differentiated stage(E7) of chick retina. The up–reguration of Wnt 9/14 expression was also confirmed by Western blot. Moreover, retinal ganglion cells have the high tendency of Wnt 9/14 specific expression in histologic and fluorescence microscopic examinations. Conclusions: This study suggest that Wnt 9/14 may have an important role of retinal differentiation.

Keywords: retina • retinal development • regeneration 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×