May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
ApoE e3 Haplotype Modulating the Risk of Alzheimer's Disease Does Not Affect the Risk of Age–Related Macular Degeneration
Author Affiliations & Notes
  • I.J. Immonen
    Ophthalmology, Helsinki University Hospital, Helsinki, Finland
  • J. Eerola
    Neurology,
    Helsinki University Hospital, Helsinki, Finland
  • P.J. Tienari
    Neurology,
    Helsinki University Hospital, Helsinki, Finland
  • T. Tervo
    Ophthalmology, Helsinki University Hospital, Helsinki, Finland
  • J. Moilanen
    Ophthalmology,
    Helsinki University Hospital, Helsinki, Finland
  • P. Ranta
    Ophthalmology,
    Helsinki University Hospital, Helsinki, Finland
  • P. Tommila
    Ophthalmology,
    Helsinki University Hospital, Helsinki, Finland
  • J. Holopainen
    Ophthalmology,
    Helsinki University Hospital, Helsinki, Finland
  • Footnotes
    Commercial Relationships  I.J. Immonen, None; J. Eerola, None; P.J. Tienari, None; T. Tervo, None; J. Moilanen, None; P. Ranta, None; P. Tommila, None; J. Holopainen, None.
  • Footnotes
    Support  Sohlbergin säätiö, Silmäsäätiö,Research foundation of the HUS
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 3201. doi:
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      I.J. Immonen, J. Eerola, P.J. Tienari, T. Tervo, J. Moilanen, P. Ranta, P. Tommila, J. Holopainen; ApoE e3 Haplotype Modulating the Risk of Alzheimer's Disease Does Not Affect the Risk of Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3201.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To evaluate, whether ApoE e3 haplotype, as defined by polymorphism at position –219 of the ApoE promoter, modulates the risk of age–related macular degeneration in subjects with the e3/e3 genotype. Methods:The e3 haplotype was analyzed in 70 e3/e3 individuals with age–related macular degeneration (AMD). Controls consisted of a population sample of 395 e3/e3 individuals from the same region, aged 65. Results:The frequency of chromosomes with the –219T haplotype was 0.436 in AMD patients and 0.411 in controls. The corresponding frequences for the –219G haplotype were 0.564 and 0.589. Conclusions:The e3 –219G haplotype, raported to be connected with an increase in the risk of Alzheimer's disease, compared to the –219T is neutral in relation to AMD.

Keywords: age-related macular degeneration • gene modifiers • retina 
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