May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
ApoE e3 Haplotype Modulating the Risk of Alzheimer's Disease Does Not Affect the Risk of Age–Related Macular Degeneration
I.J. Immonen; J. Eerola; P.J. Tienari; T. Tervo; J. Moilanen; P. Ranta; P. Tommila; J. Holopainen
Author Affiliations & Notes
  • I.J. Immonen
    Ophthalmology, Helsinki University Hospital, Helsinki, Finland
  • J. Eerola
    Neurology,
    Helsinki University Hospital, Helsinki, Finland
  • P.J. Tienari
    Neurology,
    Helsinki University Hospital, Helsinki, Finland
  • T. Tervo
    Ophthalmology, Helsinki University Hospital, Helsinki, Finland
  • J. Moilanen
    Ophthalmology,
    Helsinki University Hospital, Helsinki, Finland
  • P. Ranta
    Ophthalmology,
    Helsinki University Hospital, Helsinki, Finland
  • P. Tommila
    Ophthalmology,
    Helsinki University Hospital, Helsinki, Finland
  • J. Holopainen
    Ophthalmology,
    Helsinki University Hospital, Helsinki, Finland
  • Footnotes
    Commercial Relationships  I.J. Immonen, None; J. Eerola, None; P.J. Tienari, None; T. Tervo, None; J. Moilanen, None; P. Ranta, None; P. Tommila, None; J. Holopainen, None.
  • Footnotes
    Support  Sohlbergin säätiö, Silmäsäätiö,Research foundation of the HUS
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 3201. doi:
  • Views
  • Share
  • Tools
    • Alerts
      User Alerts
      You are adding an alert for:
      ApoE e3 Haplotype Modulating the Risk of Alzheimer's Disease Does Not Affect the Risk of Age–Related Macular Degeneration
      You will receive an email whenever this article is corrected, updated, or cited in the literature. You can manage this and all other alerts in My Account
      The alert will be sent to:
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation
      Citation

      I.J. Immonen, J. Eerola, P.J. Tienari, T. Tervo, J. Moilanen, P. Ranta, P. Tommila, J. Holopainen; ApoE e3 Haplotype Modulating the Risk of Alzheimer's Disease Does Not Affect the Risk of Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3201.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

      ×
    • Get Permissions
  • Supplements
Abstract

Abstract: : Purpose: To evaluate, whether ApoE e3 haplotype, as defined by polymorphism at position –219 of the ApoE promoter, modulates the risk of age–related macular degeneration in subjects with the e3/e3 genotype. Methods:The e3 haplotype was analyzed in 70 e3/e3 individuals with age–related macular degeneration (AMD). Controls consisted of a population sample of 395 e3/e3 individuals from the same region, aged 65. Results:The frequency of chromosomes with the –219T haplotype was 0.436 in AMD patients and 0.411 in controls. The corresponding frequences for the –219G haplotype were 0.564 and 0.589. Conclusions:The e3 –219G haplotype, raported to be connected with an increase in the risk of Alzheimer's disease, compared to the –219T is neutral in relation to AMD.

Keywords: age-related macular degeneration • gene modifiers • retina 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept