May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
The Association of Single Nucleotide Polymorphism at the Decorin, Lumican and DSPG3 Genes With Susceptibility to High Myopia
Author Affiliations & Notes
  • Y.–F. Shih
    Department of Ophthalmology, Natl Taiwan University Hosp, Taipei, Taiwan Republic of China
  • I.–J. Wang
    Department of Ophthalmology, Natl Taiwan University Hosp, Taipei, Taiwan Republic of China
  • Y.–C. Hou
    Department of Ophthalmology, Natl Taiwan University Hosp, Taipei, Taiwan Republic of China
  • L. Lin
    Department of Ophthalmology, Natl Taiwan University Hosp, Taipei, Taiwan Republic of China
  • Footnotes
    Commercial Relationships  Y. Shih, None; I. Wang, None; Y. Hou, None; L. Lin, None.
  • Footnotes
    Support  NSC91–2314–B002–294, NSC92–2314–B002–154,NSC–93–2314–B002–019
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 3209. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Y.–F. Shih, I.–J. Wang, Y.–C. Hou, L. Lin; The Association of Single Nucleotide Polymorphism at the Decorin, Lumican and DSPG3 Genes With Susceptibility to High Myopia . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3209.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: To evaluate the relationship between two single nucleotide polymorphisms (SNPs) of decorin, lumican, and DSPG3 genes and high myopia. Methods: We collected 89 adult patients with high myopia (<–10.0 D) and 111 controls with –1.5 to 0.5 D to study the association of the decorin, lumican and DSPG3 genes with high myopia. All of these subjects were free of ocular diseases except myopia and other systemic genetic diseases. Genotyping was performed by direct sequencing after PCR amplification of chromosomal DNA. Allele frequencies were tested for Hardy–Weinberg equilibrium (HWE). The Χ2 or Fishder test was conducted to investigate the genotypic and allelic distribution between high myopia and control groups. Results: The genotyping successful rate was 98%. The genotype distribution was not deviated from HWE. For decorin gene (rs2070985), there were 66 CC, 20 CG and 3 GG in case group; 82 CC, 22 CG and 4 GG in control group. For lumican gene (rs3741835), there were 49AA, 34 AG and 6 GG in case group; 48 AA, 50 CG and 13 GG in control group. For DSPG3 gene (rs1920751), there were 5 AA, 24 AG and 60 GG in case group; 7 TT, 35 TG and 70 GG in control group. There was significant difference for lumican gene between two subgroups with a p value of 0.031. However, there was no significant difference for decorin and DSPG genes. Conclusions: Our results reveal that the extracellular matrix glycosaminoglycan, especial lumican, plays an important role in the development of high myopia.

Keywords: myopia • gene screening 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×