May 2005
Volume 46, Issue 13
ARVO Annual Meeting Abstract  |   May 2005
Relationship Between Retinal Microangiopathy and Coronary Calcification
Author Affiliations & Notes
  • D. Baleanu
    Department of Ophthalmology,
    University of Erlangen–Nuremberg, Erlangen, Germany
  • J. Harazny
    Center of Preventive Medicine and Eye Diagnostics, Erlangen, Germany
  • K. Pohle
    Department of Cardiology,
    University of Erlangen–Nuremberg, Erlangen, Germany
  • W. Adler
    Department of Biostatistics and Epidemiology,
    University of Erlangen–Nuremberg, Erlangen, Germany
  • G. Michelson
    Department of Ophthalmology,
    University of Erlangen–Nuremberg, Erlangen, Germany
  • Footnotes
    Commercial Relationships  D. Baleanu, None; J. Harazny, None; K. Pohle, None; W. Adler, None; G. Michelson, None.
  • Footnotes
    Support  Deutsche Forschungsgemeinschaft KFO TP4
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 3277. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      D. Baleanu, J. Harazny, K. Pohle, W. Adler, G. Michelson; Relationship Between Retinal Microangiopathy and Coronary Calcification . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3277.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Abstract: : Purpose: To examine the relationship of retinal microangiopathic abnormalities with the amount of coronary calcium. Methods: In a prospective, cross–sectional study 88 male and 74 female subjects (30–65 years) were examined by (1) 45° retinal digital photography (KOWA Nonmydriatic fundus camera), (2) electron beam tomography or multislice spiral computed tomography of the heart and (3) Scanning Laser Doppler Flowmetry (HRF). It was evaluated the presence of generalized retinal arteriolar narrowing (arteriole–to–venule ratio = av–ratio), of retinal microangiopathic abnormalities (RMA), the amount of coronary calcium (by Agatston score) and the retinal vessel wall thickness (RVWT). The Framingham risk score was calculated. Based on the age–standardized av–ratio, the RMA and the RVWT a combined microangiopathic risk score (COMIA) with 6 levels (0 =no risk to 5=highest risk) was calculated. Statistics were performed by SPSS 10.0 (correlations and logistic regression analysis , *p<0.05, **p<0.001). Results: The av–ratio and the COMIA risk score correlated significantly with the Framingham risk score (r=–0.210*; respectively r= 0.301**) and the Agatston score (r = –0.189*; respectively r=0.186*). The COMIA risk score significantly modeled the Agatston score (p< 0.05). In male subjects the correlations between COMIA vs. Framinghman and COMIA vs. Agatston were stronger (r=0.506**, r=0.385**). In comparison to patients in COMIA risk groups 0–4 the relative risk of male subjects in the highest COMIA risk group 5 was 1.7 times higher to have coronary calcifications (RR 1.752; OR 4.307). In contrast, in female subjects we did not find any significant correlations. Conclusions: Generalized retinal arteriolar narrowing and retinal microangiopathic abnormalities were significantly associated with the amount of coronary calcification. The retinal risk score COMIA might be a new prognostic tool in prevention medicine concerning coronary heart disease events.

Keywords: retina • clinical (human) or epidemiologic studies: risk factor assessment • clinical (human) or epidemiologic studies: treatment/prevention assessment/controlled 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.