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C.G. Kiss, R. Leitgeb, S. Michels, B. Hermann, C. Ahlers, B. Povazay, S. Sacu, H. Sattmann, U. Schmidt–Erfurth, W. Drexler; Retinal Vasculature Imaging Using Three Dimensional Ultra–High Resolution Optical Coherence Tomography . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3467.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To image the physiologic retinal vascular network in the macula using three–dimensional ultra–high resolution optical coherence tomography (3D UHR OCT). Methods: 20 eyes of healthy young volunteers were imaged using a second generation ultrahigh resolution OCT system for three–dimensional video–rate retinal imaging employing a compact, commercially available ultrabroad bandwidth (160 nm) Titanium:shappire laser. Three dimensional retinal imaging can be performed with high axial resolution of 3µm and up to 25 B–scans/second, each tomogram consisting of 1024x1024 pixels, resulting in 25 Megavoxels/second. Results: 3 D UHR OCT images the multi–layer retinal vascular system in its horizontal and in its depth extension. Retinal capillaries are seen in the macula – comparable to histology – in two major capillary layers within the nerve–fiber layer and the inner nuclear layer. In addition to vertical cuts of retinal vessels showing round vascular lumen and an accompanying, small reflectance shadow, the vascular network can be demonstrated in its horizontal extent comparable to angiographic imaging. The 3D UHR–OCT further demonstrates the maximal depth of the intraretinal capillary network reaching to the medial limiting membrane. A change in the perifoveal vascular architecture to a truncated cone distribution with a central sparing representing the foveal avascular zone is shown. Conclusions: 3D UHR OCT imaging allows visualization of the three–dimensional retinal vascular network with its characteristic vascular pattern. 3D UHR OCT could become a useful tool for diagnosis and follow–up retinal vascular disease.
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