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L.M. Zangwill, R.N. Weinreb, J.A. Beiser, G.A. Cioffi, A.L. Coleman, G. Trick, J.M. Liebmann, M.A. Kass, M.O. Gordon, OHTS CSLO Ancillary Study Group; Baseline Topographic Optic Disc Measurements Are Associated With the Development of Primary Open Angle Glaucoma: The Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the OHTS . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3631.
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Purpose: To determine whether baseline confocal scanning laser ophthalmoscopy (CSLO) optic disc topographic measurements are associated the development of primary open angle glaucoma (POAG) in individuals with ocular hypertension. Methods: Eight hundred and sixty five eyes from 438 participants in the CSLO Ancillary Study to the Ocular Hypertension Treatment Study (OHTS) with good quality baseline CSLO images were included in this study. Each baseline CSLO parameter was assessed in univariate and multivariate proportional hazards models to determine its association with the development of POAG. Results: Forty–one eyes from 36 CSLO Ancillary Study participants developed POAG. Several baseline topographic optic disc measurements were significantly associated with the development of POAG in both univariate and multivariate analysis including larger cup–to–disc area ratio, mean cup depth, mean height contour, cup volume, reference plane height, and smaller rim area, rim area to disc area, and rim volume. In addition, classification as "outside normal limits" by the Heidelberg Retina Tomograph (HRT) "Classification" and the Moorfields Regression Analysis (MRA) (overall, global, temporal inferior, nasal inferior and superior temporal regions) classifications were significantly associated with the development of POAG. Within the follow–up period of this analysis, the predictive value of a positive test of CSLO indices, ranged from 14% (HRT Classification and MRA Overall) to 40% for MRA temporal superior. Conclusions: Several baseline topographic optic disc measurements alone or when combined with baseline clinical and demographic factors were significantly associated with the development of POAG among OHTS participants. Longer follow–up is required to evaluate the true predictive accuracy of CSLO measures.
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