May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
A Comparison of False–Positive Test Results Between the Stratus OCT III and the GDx–VCC
Author Affiliations & Notes
  • J. Stein
    Ophthalmology, New York University, New York, NY
    Ophthalmology, Manhattan Eye, Ear, and Throat Hospital, New York, NY
  • C.A. Girkin
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • N. Harizman
    Ophthalmology, New York Eye and Ear Infirmary, New York, NY
  • S. Arthur
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • A. Chiang
    Ophthalmology, New York University, New York, NY
  • J.D. Ortega
    Ophthalmology, University of Alabama at Birmingham, Birmingham, AL
  • J.M. Liebmann
    Ophthalmology, New York University, New York, NY
    Ophthalmology, Manhattan Eye, Ear, and Throat Hospital, New York, NY
  • C. Tello
    Ophthalmology, Manhattan Eye, Ear, and Throat Hospital, New York, NY
    Ophthalmology, New York Eye and Ear Infirmary, New York, NY
  • R. Ritch
    Ophthalmology, New York Eye and Ear Infirmary, New York, NY
    Ophthalmology, New York Medical College, New York, NY
  • Footnotes
    Commercial Relationships  J. Stein, None; C.A. Girkin, None; N. Harizman, None; S. Arthur, None; A. Chiang, None; J.D. Ortega, None; J.M. Liebmann, None; C. Tello, None; R. Ritch, None.
  • Footnotes
    Support  NIH EY13959–01
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 3635. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      J. Stein, C.A. Girkin, N. Harizman, S. Arthur, A. Chiang, J.D. Ortega, J.M. Liebmann, C. Tello, R. Ritch; A Comparison of False–Positive Test Results Between the Stratus OCT III and the GDx–VCC . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3635.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Abstract: : Purpose: To compare the proportions of false–positive findings with optical coherence tomography (OCT) and scanning laser polarimetry in an independent cohort of participants with healthy eyes. Methods: Monocular Stratus OCT–3 imaging and GDx scanning with variable cornea compensation (VCC) were performed in 234 prospectively enrolled participants with no evidence of glaucoma based on optic nerve head stereoscopic photography (assessed by masked review), repeated intraocular pressure measurement (<21 mm Hg), and achromatic perimetry. Participants were considered to have false–positive findings on OCT–3 imaging if the mean retinal nerve fiber layer (RNFL) thickness or the RNFL thickness of at least one quadrant was abnormal (based on 99% confidence intervals [CI] for normative values). GDx VCC findings were considered false–positive if the mean temporal, superior, nasal, inferior, temporal (TSNIT) score or the RNFL value in at least one quadrant was abnormal (based on 99% CI). Results: With OCT–3, RNFL thickness values were abnormal in one quadrant only for 21 eyes (9% of participants), in two quadrants only for seven eyes (3.1%), and in three or more quadrants for four eyes (1.7%). GDx VCC scanning indicated an abnormality in one quadrant only for 21 eyes (9.0%), in two quadrants only for six eyes (2.6%), and in three or more quadrants for two eyes (0.85%). Global measurement for OCT–3 (mean RNFL thickness) was abnormal in five eyes (2.1%), and for GDx VCC (mean TSNIT score) in nine eyes (3.8%). The techniques did not differ in the proportion of eyes with false–positive findings for global measurement (p = 0.07) or for one quadrant only (p = 1.0), two quadrants only (p = 0.36), or three or more quadrants (p = 0.69). The agreement between techniques was poor (highest Κ = 0.27, for global RNFL thickness). Conclusions: The OCT–3 and the GDx VCC had similar proportions of false–positive findings but tended to identify different eyes as abnormal. To maintain a false–positive rate of 4% or less, the global indicators can be used. However, achieving a false–positive rate of 1% or less would require demonstration of an abnormality in three or more quadrants on the GDx VCC. Currently, it does not appear possible to achieve a false–positive rate of 1% or less with OCT.

Keywords: nerve fiber layer • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×