Evaluating Available Parameters for Identifying Abnormality on Frequency Doubling Technology Perimetry in the Diagnostic Innovations in Glaucoma Study (DIGS)

Abstract

 

Abstract:

 

To evaluate global indices and point–wise criteriafor abnormality in Frequency Doubling Technology Perimetry (FDT)N–30, a visual function specific test targeting magnocellularganglion cells.

 

One eye of 259 participants was evaluated: 51 normals,56 ocular hypertensives (OHT), 118 eyes with glaucomatous opticneuropathy (GON) and 34 with progressive GON (PGON), a morestringent criteria to increase odds glaucoma is present. Visualfields were not used to classify groups. PGON, the best goldstandard currently available for evaluation of functional tests,was documented by evidence of progressive change in optic discappearance on masked review of simultaneous stereophotographsby two experts. We assessed areas under the ROC for indicesand number of defective locations at various probabilities onthe pattern and total deviation plots using area under the ROC.ROC results were then used to establish criteria for abnormalityat different specificities.

 

Subset of results below for parameters with largerROC areas.

 

 

 

When comparing visual function specific tests witheach other, with standard perimetry, or with measures of opticnerve structure it is important to utilize the best criteriafor abnormality for each type of test. It is also importantto take into account the trade–off in sensitivity vs.specificity for the particular use in question. The FDT N–30test performs well in separating normal and glaucomatous eyesusing a variety of parameters as evidenced by the large areaunder the ROC.

 

 

Keywords: perimetry • visual fields