May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Agreement Between Standard Automated Perimetry and Heidelberg Retina Tomograph for Detecting Glaucoma in the Diagnostic Innovations in Glaucoma Study (DIGS)
D. Ng; L.M. Zangwill; J.P. Pascual; R.R. Bourne; C. Bowd; C. Boden; R.N. Weinreb; P.A. Sample
Author Affiliations & Notes
  • D. Ng
    Hamilton Glaucoma Center, Department of Ophthalmology, Univ of California–San Diego, La Jolla, CA
  • L.M. Zangwill
    Hamilton Glaucoma Center, Department of Ophthalmology, Univ of California–San Diego, La Jolla, CA
  • J.P. Pascual
    Hamilton Glaucoma Center, Department of Ophthalmology, Univ of California–San Diego, La Jolla, CA
  • R.R. Bourne
    Hamilton Glaucoma Center, Department of Ophthalmology, Univ of California–San Diego, La Jolla, CA
  • C. Bowd
    Hamilton Glaucoma Center, Department of Ophthalmology, Univ of California–San Diego, La Jolla, CA
  • C. Boden
    Hamilton Glaucoma Center, Department of Ophthalmology, Univ of California–San Diego, La Jolla, CA
  • R.N. Weinreb
    Hamilton Glaucoma Center, Department of Ophthalmology, Univ of California–San Diego, La Jolla, CA
  • P.A. Sample
    Hamilton Glaucoma Center, Department of Ophthalmology, Univ of California–San Diego, La Jolla, CA
  • Footnotes
    Commercial Relationships  D. Ng, None; L.M. Zangwill, Heidelberg Engineering F; Carl Zeiss Meditec F; Laser Diagnostic Technologies F; J.P. Pascual, None; R.R. Bourne, Heidelberg Engineering F; C. Bowd, None; C. Boden, None; R.N. Weinreb, Heidelberg Engineering F; Carl Zeiss Meditec F; Laser Diagnostic Technologies F; P.A. Sample, Carl Zeiss Meditec F.
  • Footnotes
    Support  NIH Grant EY08208(PAS) EY11008(LMZ) TFC Frost, UK(RRB)
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 3746. doi:
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      D. Ng, L.M. Zangwill, J.P. Pascual, R.R. Bourne, C. Bowd, C. Boden, R.N. Weinreb, P.A. Sample; Agreement Between Standard Automated Perimetry and Heidelberg Retina Tomograph for Detecting Glaucoma in the Diagnostic Innovations in Glaucoma Study (DIGS) . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3746.

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Abstract

Abstract: : Purpose:To assess the agreement between structural and functional testing for detecting glaucoma using standard automated perimetry (SAP) and Heidelberg Retina Tomograph I (HRT I) at 2 different visits. Methods:Fifty–nine eyes of 59 glaucoma patients or suspects (mean age 61.8 ± SD 11.9) were tested at two visits completed within 15 months with both SAP (Swedish Interactive Threshold Algorithm, program 24–4) and HRT I. The agreement between detecting abnormality using SAP (pattern standard deviation at p<1% or a glaucoma hemifield test of outside normal limits) and the HRT (Moorfields Classification Result outside normal limits) at the 2 visits was compared. Results:At Visit 1, 11 eyes (18.6%) were classified as glaucoma by both SAP and HRT, 9 eyes (15.3%) by SAP alone, 9 eyes (15.3%) by HRT alone and 30 eyes (50.8%) were classified as normal by both tests (kappa=0.32 with 69% agreement). At Visit 2, 17 eyes (28.8%) were classified as glaucoma by both SAP and HRT, 11 eyes (18.6%) by SAP alone, 4 eyes (6.8%) by HRT alone and 27 eyes (45.8%) were classified as normal by both tests (kappa=0.48 with 74% agreement). All 11 eyes classified by both tests at Visit 1 were also classified by both tests at Visit 2. Of the 9 eyes classified by SAP alone at Visit 1, 7 were classified by SAP alone at Visit 2 and the remaining 2 eyes were classified by both SAP and HRT. Of the 9 eyes classified by HRT alone at Visit 1, 3 were classified by HRT alone at Visit 2, 4 were classified by HRT and SAP, and 2 were normal on both tests. 25 of the 30 eyes classified as normal by both SAP and HRT at Visit 1 were classified as normal at Visit 2. The 18 eyes that were classified as glaucoma by only one test at Visit 1 had less severe glaucoma (median MD=–1.56) than the 11 eyes (median MD=–4.39) that were classified as glaucoma by both tests. Conclusions:Agreement between SAP SITA and HRT for classifying eyes as glaucoma or normal was high and repeatable over time. The result that eyes classified as glaucoma by either SAP or HRT, but not both, had less severe visual field damage suggests that both structural and functional tests are important for detecting early glaucoma.

Keywords: visual fields • imaging/image analysis: clinical • perimetry 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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