May 2005
Volume 46, Issue 13
ARVO Annual Meeting Abstract  |   May 2005
Comparison of Bimatoprost and Latanoprost for Treatment of Glaucoma in a Veterans Population
Author Affiliations & Notes
  • S. Knapp
    Ophthalmology, Univ Texas Southwestern, Dallas, TX
  • B.R. Sullivan
    Ophthalmology, Univ Texas Southwestern, Dallas, TX
  • Footnotes
    Commercial Relationships  S. Knapp, None; B.R. Sullivan, None.
  • Footnotes
    Support  Research to Prevent Blindness, Inc.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 3761. doi:
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      S. Knapp, B.R. Sullivan; Comparison of Bimatoprost and Latanoprost for Treatment of Glaucoma in a Veterans Population . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3761.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose:To compare the intraocular pressure (IOP) lowering efficacy of topical bimatoprost 0.03% with latanoprost 0.005%. Methods: Glaucoma patients treated at the Dallas VAMC with latanoprost 0.005% (Xalatan®) were initially included in this retrospective chart review. Intraocular pressures of eligible subjects were recorded before and after a VA Pharmacy Service auto–substitution from latanoprost to bimatoprost 0.03% (Lumigan®). The patients’ age, gender, race, type of glaucoma, and side effects of treatment were also recorded. Patients with confounding treatment variables were not included for data analysis. Results: 1060 patients had undergone an auto–substitution from latanoprost to bimatoprost. Of these, 139 (13.1%) subjects had no identifiable confounding variables and were included in the study. The mean IOP was 0.62 mm Hg lower on bimatoprost than on latanoprost (P = 0.183; ANOVA). Bimatoprost was significantly more effective than latanoprost using pairwise comparison (P <.03; paired t–tests). Three (2.2%) patients complained of conjunctival hyperemia after the change from latanoprost to bimatoprost. Conclusions:This study suggests that bimatoprost may be slightly more effective in lowering IOP than latanoprost in a veterans population.

Keywords: drug toxicity/drug effects • pharmacology 

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