Purchase this article with an account.
N. Izumi, T. Nagaoka, E. Sato, F. Mori, A. Yoshida; Influence to Retinal Blood Flow by Mild Ischemia Reperfusion in Cats . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3901.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose:It is said that retinal blood flow is hyperemic during the early phase of reperfusion after ischemia. But the hemodynamic changes by mild ischemia reperfusion that does not cause an irreversible tissue injury are not yet fully understood. We reviewed influence to retinal blood flow by mild ischemia reperfusion in cats. Methods:16 adult cats were used in this study. The animals were anesthetized with enflurane and mechanically ventilated. We fixed a 26G needle in anterior chamber and connected to oxiglutathione ophthalmic perfusate (BSS PLUS, Alcon, Tokyo, Japan). We set intraocular pressure in 40, 50, 60, 70mmHg by the height of perfusate each and burdened ischemia of 5 minutes. We measured vessel diameter and blood velocity simultaneously until 15 minutes after ischemia and calculated retinal blood flow with a laser Doppler velocimetry system (CLBF model 100, Canon, Tokyo, Japan). Results:During 15 minutes after ischemia, retinal blood flow increased 32.8 +– 1.7% (mean +– standard error) of baseline at the maximum, 50.8 +– 2.9%, 70.8 +– 3.8%, 84.1 +– 4.1% in groups of intraocular pressure 40, 50, 60, 70mmHg, respectively. Conclusions:Retinal blood flow was hyperemic after mild ischemia reperfusion in cats.
This PDF is available to Subscribers Only