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A. Takahashi, T. Nagaoka, H. Yokota, N. Izumi, A. Yoshida; Effect of Topical Brinzolamide on Retinal and Choroidal Circulation in Normal Human Eyes . Invest. Ophthalmol. Vis. Sci. 2005;46(13):3929.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To determine the short– and long–term effects of topical 1% brinzolamide , a new carbonic anhydrase inhibitor, on retinal and choroidal circulation in normal human eyes. Methods:Twelve healthy volunteers received instillation of 1% brinzolamide in one eye and physiological saline in the fellow eye. Retinal arterial blood flow (RBF) was measured using a retinal laser Doppler velocimeter (Canon, CLBF 100). choroidal blood flow (CBF) in the foveal region were recorded using laser Doppler flowmeter (Oculix 4000). Pulsatile ocular blood flow (POBF) was measured using a Langham OBF tonometer. Blood pressure, heart rate, intraocular pressure (IOP), RBF, CBF, POBF were measured before treatment, 90 minutes after the initial instillation of brinzolamide, and after the last instillation on the 14 days twice daily. Results: After 14 days of instillation, the IOP tended to decrease. The RBF, CBF and RBV did not change significantly in the brinzolamide–treated eyes compared with the baseline after 90 min and 14 days. Conclusions:Our results for the first time indicated that, unlike some ß –blocking agents, topical brinzolamide does not decrease retinal and choroidal blood flow in healthy human eyes.
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