Abstract
Abstract: :
Purpose:To determine whether calcium palmitate (a cause of asteroid hyalosis), cholesterol (a cause of synchysis scintillans), triamcinolone acetonide, and 11–deoxycortisol (a precursor of cortisol in steroid metabolism) could be used as tools for visualization of the vitreous body in the anterior chamber after posterior capsule rupture in animal model. Methods:In porcine eyes, suspension of calcium palmitate, cholesterol, triamcinolone acetonide, and 11–deoxycortisol was injected in the anterior chamber after phacoemulsification and intentionally creating posterior capsule rupture. Following gentle irrigation and aspiration, the vitreous body in the anterior chamber was observed under a surgical microscope. In rabbit eyes, the side effects of the lipid formulae were assessed for biomicroscopic appearance, intraocular pressure, and corneal histology. Results:All the suspensions were effective in visualizing the vitreous body prolapsed in the anterior chamber. Cholesterol and calcium palmitate injected in the anterior chamber induced significant increase in the intraocular pressure and corneal edema. In contrast, triamcinolone acetonide and 11–deoxycortisol had no significant effect on an intraocular pressure or corneal histology. However, triamcinolone acetonide injected in the vitreous cavity lead significant increase in the intraocular pressure at two and four weeks after the injection. In contrast, 11–deoxycortisol injected in the vitreous cavity did not affect the intraocular pressure. Conclusions:Cholesterol and calcium palmitate were not suited for ocular surgery. The suspension of triamcinolone acetonide and 11–deoxycortisol were effective in visualizing the vitreous body prolapsed in the anterior chamber after posterior capsule rupture. However, triamcinolone acetonide left in the vitreous cavity would be a cause of post–operative late–onset ocular hypertension.
Keywords: vitreous • retina