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H. Holmberg, B. Bauer, C. Hvarfner, M. Lövestam–Adrian, V. Ponjavic; A Characterization of Morphology and Function of the Posterior Pole in Affected and Fellow Eyes in Patients With Central Serous Retinopathy . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4061.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To characterize morphology and function in patients with central serous retinopathy. Methods: Six patients with central serous retinopathy (CSR) (age 37–46 years; mean + SD, 42,0 + 3,4) underwent Fluorescein angiography (FA), Indocyanine Green angiography (ICGA), Optical coherence tomography (OCT), Multifocal electroretinography (mERG), testing of color vision and assessment of visual acuity (VA), of the affected and fellow eye within three weeks after presentation of symptoms, and at 3 and 6 months. Control data from subjects without eye disease was obtained for OCT (6 subjects, age 32–47 years; mean + SD, 41,3 + 6,3) and mfERG (17 subjects, age 31–56 years; mean + SD, 45,5 + 8,0). Results:Best corrected VA in affected eyes remained stable through all test occasions in 3 patients, improved by 1 or 2 lines in 2 patients and deteriorated 3 lines in one patient. VA in fellow eyes was unchanged in 1 patient, improved in 2 patients and deteriorated 1 line in 2 patients. In affected eyes color vision defects were seen in 3 patients at 3 weeks, 2 at 3 months and 1 at 6 months. There were no defects of color vision of fellow eyes at any test time. On fundoscopy fellow eyes were normal in 3 patients, 2 had minimal mottling of the pigment epithelium and one patient had pigment epithelial detachment (PED). All affected eyes had typical CSR findings on FA and ICGA. Three of the fellow eyes showed a PED, and in two of these focal hyperfluorescence was present on ICGA representing choroidal hyperpermeability. At three weeks the most central ring in the affected eye showed a prolonged implicit time (IT) on the mfERG response compared to normals; p=0.014, whereas the fellow eye showed a tendency towards a prolonged implicit time but the difference was not statistically significant; p=0.078. A comparison of affected eyes with fellow eyes did not demonstrate any difference in IT at 3 weeks and 3 months but at 6 months there was a statistically significant difference, with a normalized IT in the fellow eye. OCT demonstrated an increased central thickness in the affected eye compared to both the fellow eye and to normal subjects. Conclusions: CSR is characterized by an increased retinal thickness and a reduced function (prolonged implicit time) in the affected eye. The fellow eye frequently demonstrates pathology in angiography and function indicating a considerable and simultaneous disease activity despite minimal changes in fundus appearance.
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