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S.G. Bhandarkar, D.J. Salchow, M.F. Chiang, J.T. Flynn, T.C. Lee; Correlation between Increased Weight Gain and Onset of Threshold Retinopathy of Prematurity . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4096.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To determine whether mean weight gain in low birth weight infants is correlated with increased incidence of threshold Retinopathy of Prematurity (ROP). Methods: Medical charts of all inpatients that were diagnosed with threshold ROP from 2001 to 2004 at NY Presbyterian Hospital (Cornell and Columbia campuses) were reviewed. Weight–matched control patients who did not develop threshold ROP were identified for comparison. The mean daily weight gain for the 4 weeks prior to the day of threshold ROP diagnosis was determined. Weight–matched control patients who did not develop threshold ROP were identified and mean daily weight gains for the corresponding 4 weeks were determined. Results between threshold ROP and control subjects were compared based on initial birth weight. Results: 28 threshold and 40 control subjects were analyzed. Mean daily weight gain (weight class) over the 4 weeks prior to threshold ROP was 17.73 g/day (500–599g), 27.69 g/day (600–699g), 29.74 g/day (700–799g), 26.81 g/day (800–899g) and 28.62 g/day (900–999g). Mean daily weight gain (weight class) over the corresponding 4 weeks in controls was 18.84 g/day (500–599g), 22.51 g/day (600–699g), 19.52 g/day (700–799g), 22.73 g/day (800–899g), and 23.42 g/day (900–999g). The mean overall weight gain in threshold ROP patients was 26.28 g/day, compared to 21.82 g/day in control patients. Conclusions: Onset of threshold ROP may be associated with an increase in weight gain over the 4–week period leading up to the day of diagnosis which may be useful for identifying infants who are at increased risk for developing threshold ROP.
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