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J. Flynn, T. Chan–Ling; New Conception of Retinopathy of Prematurity (ROP): Zone 1 versus Zone 2 ROP . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4110.
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Results of current therapy of Zone 1 compared to Zone2 ROP are disappointing (Table 1).
RESULTS OF THERAPY : ZONE 1 VS ZONE 2
Digital images correlated with the 2 distinct processesof retinal vascularizationin Zone 1&2 provide a rationalbasis for the discrepency in the clinical outcome of therapy.What emerges is a picture of bi–phasic ROP: VasculogenicROP, indepedent of metabolic demand, poorly responsive to ablativetherapy, and Angiogenic ROP responsive to therapywhich reducesmetabolic demand . Clinical differences are summarized (Table2).
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