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H. Ozaki, N. Umeda, T. Shitama, H. Hayashi, K. Oshima; Vascular Endothelial Growth Factor Level in Stage5 Retinopathy of Prematurity . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4128.
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Purpose:Selecting a suitable timing for surgeries on stage 5 retinopathy of prematurity (ROP) is critical. Vitrectomies performed too early before the ceasing of the angiogenic activity may bring about high risks of angiogenic blood vessel–related complications. We have investigated the time course of intraocular vascular endothelial growth factor (VEGF) level, the principal angiogenesis factor, as an indicatot of ocular angiogenic activity in stage 5 ROPs and evaluate a suitable timing for surgical intervention. Methods:Vitreous fluids were obtained from 26 eyes from 23 patients with stage 5 ROP during vitrectomy at Fukuoka University Hospital from June 1997 to June 2003. VEGF concentrations in the vitreous fluids were determined by enzyme linked immunosorbent assay. Results:VEGF concentrations in vitreous samples ranged from 8138.4 to 0 pg/ml (Mean ± SD; 850.1 ± 2005.6 pg/ml). VEGF concentrations were comparitively elevated in eyes within 7 month after birth at the time of surgery (Mean ± SD; 1334.4 ± 2458.4 pg/ml) compared to those of the eyes later than 8 month after birth (Mean ± SD; 75.4 ± 130.0 pg/ml). (P < 0.05). Conclusions:A decrease in the intraocular concentration of VEGF was shown in patients after 8 months of age in stage 5 ROP. This may suggest a favorable timing for surgeries with less complications associated with milder angiogenic activity.
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