May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Prediction of Inhibitive Activity of Endostatin in vitro by Gene Expression Profiling
M. Yan; M. Zhang; R.A. Adelman; J. Zhang; Y. Liu; F. Lu
Author Affiliations & Notes
  • M. Yan
    West China Eye Center, West China Hospital, Sichuan University, Chengdu, China
  • M. Zhang
    West China Eye Center, West China Hospital, Sichuan University, Chengdu, China
  • R.A. Adelman
    Yale Eye Center., Yale University School of Medicine, CT
  • J. Zhang
    West China Eye Center, West China Hospital, Sichuan University, Chengdu, China
  • Y. Liu
    West China Eye Center, West China Hospital, Sichuan University, Chengdu, China
  • F. Lu
    West China Eye Center, West China Hospital, Sichuan University, Chengdu, China
    Yale Eye Center, Yale University School of Medicine, CT
  • Footnotes
    Commercial Relationships  M. Yan, None; M. Zhang, None; R.A. Adelman, None; J. Zhang, None; Y. Liu, None; F. Lu, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 4199. doi:
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      M. Yan, M. Zhang, R.A. Adelman, J. Zhang, Y. Liu, F. Lu; Prediction of Inhibitive Activity of Endostatin in vitro by Gene Expression Profiling . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4199.

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Abstract

Abstract: : Purpose: To predict the inhibitive activity on retianl microvascular endothelial cells of endostatin by gene expression profiling. To predict the inhibitive activity on retianl microvascular endothelial cells of endostatin by gene expression profiling. Methods: Human retianl microvascular endothelial cells were cultured with 2500ng/ml endostatin for 24h, then the total RNA was extracted and analyzed by hybridized with BiostarH–40S gene expression DNA microarrays. Results: Approximately 5.96% of all human genes examined on 4096 gene microarrays exhibited altered expression, with 5.49% showing down–regulation and 0.47% showing up–regulation. Endostatin down–regulated genes encoding for cell proliferation, migration and differentiation. Conclusions: Down–regulation of those genes by endostatin may result in a potent antiangiogenesis effect.

Keywords: gene microarray • retinal culture 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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