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L.A. Mawn, K. Joos, J.–H. Shen; Orbital Endoscopy in Live Animal Model . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4207.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: We have been developing an orbital endoscope for use with the free electron laser (FEL). Our studies conducted to date have evaluated visualization media and surgical technique modification of endoscopic optic nerve sheath fenestration (ONSF) in pig cadavers and fresh human cadavers. This study was conducted to utilize and further modify an author designed orbital endoscope for use with the FEL in a live animal model. Methods: An experimental study utilizing an author designed laser delivery system through an endoscope was conducted. Ten live adult pigs had orbital endoscopy performed to develop a method of ONSF with the FEL. Twenty orbits were used to modify the surgical procedure. An ONSF was performed using the FEL (6.45 µm, 30 Hz, 2–3mJ, 250 µm spot size) through a glass hollow waveguide introduced through an endoscope in twenty orbits. Results: A dural window was made using the FEL through a glass hollow waveguide adapted to both the flexible Olympus HYF–XP endoscope and the rigid Storz Pedi–cystourethroscope with the FEL. Histological evidence of the ONSF was produced. Conclusions: A hollow waveguide capable of transmitting the FEL through an endoscope was successfully constructed and used in a live animal model. ONSF using the FEL applied via an endoscope is technically feasible. Additional studies are currently examining techniques to improve orbital endoscopy.
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