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R.A. Rejdak, C. Rummelt, F. Schuettauf, E. Zrenner, Z. Zagorski, T. Zarnowski, U. Schlötzer–Schrehardt, G.O. H. Naumann, F. Kruse, A.G. M. Junemann; Expression of L–Kynurenine Aminotransfrases in Corpora Amylacea in the Human Retina and Optic Nerve . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4241.
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Purpose: Corpora amylacea (CAm) occur in optic nerve and retinal ageing and degeneration. Cellular expression of L–kynurenine aminotransferases (KAT I and II) in the retina and its changes in retinal development and neurodegeneration have been documented. This study examines KAT I and II immunoreactivity in CAm in the human retina and optic nerve. Methods: Immunohistochemistry was performed using polyclonal antibodies against KAT I and KAT II on sections of 5 human eyes enucleated for malignant uveal melanoma. Occurrence and location of KAT I or KAT II –stained CAm was compared with PAS–stained sections. Results: KAT I and KAT II expression in CAm was shown in the retina and optic nerve with similar location to PAS–stained sections. KAT I immunoreactivity was more intense than KAT II and its staining was more pronounced in the retrolaminar part of the optic nerve. Some of CAm showed only faint KAT II expression and occasionally there was no staining. KAT II revealed no association of staining variability and localisation of CAm. Conclusions: Expression of KATs in CAm in the human retina and optic nerve suggest that both enzymes may be involved in mechanisms of retinal ageing and neurodegeneration leading to CAm formation. SUPPORTED BY THE MARIE CURIE INDIVIDUAL FELLOWSHIP (CONTRACT NUMBER: QLK2–CT–2002–51562)
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