May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Expression of L–Kynurenine Aminotransfrases in Corpora Amylacea in the Human Retina and Optic Nerve
R.A. Rejdak; C. Rummelt; F. Schuettauf; E. Zrenner; Z. Zagorski; T. Zarnowski; U. Schlötzer–Schrehardt; G.O. H. Naumann; F. Kruse; A.G. M. Junemann
Author Affiliations & Notes
  • R.A. Rejdak
    Pathophysiology Vision, University Eye Hospital, Tubingen, Germany
  • C. Rummelt
    Department of Ophthalmology and Eye Hospital, University of Erlangen–Nuernberg, Erlangen, Germany
  • F. Schuettauf
    Pathophysiology Vision, University Eye Hospital, Tubingen, Germany
  • E. Zrenner
    Pathophysiology Vision, University Eye Hospital, Tubingen, Germany
  • Z. Zagorski
    Tadeusz Krwawicz Chair of Ophthalmology and 1st Eye Hospital, Medical University of Lublin, Lublin, Poland
  • T. Zarnowski
    Tadeusz Krwawicz Chair of Ophthalmology and 1st Eye Hospital, Medical University of Lublin, Lublin, Poland
  • U. Schlötzer–Schrehardt
    Department of Ophthalmology and Eye Hospital, University of Erlangen–Nuernberg, Erlangen, Germany
  • G.O. H. Naumann
    Department of Ophthalmology and Eye Hospital, University of Erlangen–Nuernberg, Erlangen, Germany
  • F. Kruse
    Department of Ophthalmology and Eye Hospital, University of Erlangen–Nuernberg, Erlangen, Germany
  • A.G. M. Junemann
    Department of Ophthalmology and Eye Hospital, University of Erlangen–Nuernberg, Erlangen, Germany
  • Footnotes
    Commercial Relationships  R.A. Rejdak, None; C. Rummelt, None; F. Schuettauf, None; E. Zrenner, None; Z. Zagorski, None; T. Zarnowski, None; U. Schlötzer–Schrehardt, None; G.O.H. Naumann, None; F. Kruse, None; A.G.M. Junemann, None.
  • Footnotes
    Support  THE MARIE CURIE INDIVIDUAL FELLOWSHIP TO ROBERT REJDAK (CONTRACT NUMBER: QLK2–CT–2002–51562)
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 4241. doi:
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      R.A. Rejdak, C. Rummelt, F. Schuettauf, E. Zrenner, Z. Zagorski, T. Zarnowski, U. Schlötzer–Schrehardt, G.O. H. Naumann, F. Kruse, A.G. M. Junemann; Expression of L–Kynurenine Aminotransfrases in Corpora Amylacea in the Human Retina and Optic Nerve . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4241.

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Abstract

Abstract: : Purpose: Corpora amylacea (CAm) occur in optic nerve and retinal ageing and degeneration. Cellular expression of L–kynurenine aminotransferases (KAT I and II) in the retina and its changes in retinal development and neurodegeneration have been documented. This study examines KAT I and II immunoreactivity in CAm in the human retina and optic nerve. Methods: Immunohistochemistry was performed using polyclonal antibodies against KAT I and KAT II on sections of 5 human eyes enucleated for malignant uveal melanoma. Occurrence and location of KAT I or KAT II –stained CAm was compared with PAS–stained sections. Results: KAT I and KAT II expression in CAm was shown in the retina and optic nerve with similar location to PAS–stained sections. KAT I immunoreactivity was more intense than KAT II and its staining was more pronounced in the retrolaminar part of the optic nerve. Some of CAm showed only faint KAT II expression and occasionally there was no staining. KAT II revealed no association of staining variability and localisation of CAm. Conclusions: Expression of KATs in CAm in the human retina and optic nerve suggest that both enzymes may be involved in mechanisms of retinal ageing and neurodegeneration leading to CAm formation. SUPPORTED BY THE MARIE CURIE INDIVIDUAL FELLOWSHIP (CONTRACT NUMBER: QLK2–CT–2002–51562)

Keywords: pathology: human • retinal degenerations: cell biology • aging 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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