May 2005
Volume 46, Issue 13
ARVO Annual Meeting Abstract  |   May 2005
Methodology of Retinal Thickness Measurement With the SLO
Author Affiliations & Notes
  • T.J. Holmes
    AutoQuant Imaging, Inc., Watervliet, NY
    Rensselaer Polytechnic Institute, Troy, NY
  • S.K. Pakin
    AutoQuant Imaging, Inc., Watervliet, NY
  • B. Northan
    AutoQuant Imaging, Inc., Watervliet, NY
  • N. Hutchings
    University of Waterloo, Waterloo, ON, Canada
  • J. Flanagan
    University of Watlerloo, Waterloo, ON, Canada
    University of Toronto, Toronto, ON, Canada
  • Footnotes
    Commercial Relationships  T.J. Holmes, AutoQuant Imaging, Inc. E; S.K. Pakin, AutoQuant Imaging, Inc. E; B. Northan, AutoQuant Imaging, Inc. E; N. Hutchings, AutoQuant Imaging, Inc. F; J. Flanagan, Heidelberg Engineering R; AutoQuant Imaging, Inc. F.
  • Footnotes
    Support  NIH R43EY014083
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 4271. doi:
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    • Get Citation

      T.J. Holmes, S.K. Pakin, B. Northan, N. Hutchings, J. Flanagan; Methodology of Retinal Thickness Measurement With the SLO . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4271.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract: : Purpose: To present software algorithms for measuring retinal thickness with the SLO, including methods for artifact detection and management. Methods: The backscattered light intensity profiles, along the z axis, of the SLO image stack carry an abundance of information about the layers that lay between the internal limiting membrane (ILM) and the retinal pigment epithelium (RPE). By using simple, realistic, knowledge based algorithms based on the optics of the eye, it is possible to determine if the profiles result from normal assumptions of the anatomical structure, or if they are likely the result from specific adversities. Such adversities include extensive cystoid edema and macular holes. Results: Example results are shown with images that contain cystoid edema, macular holes and other adversities. It is shown that, for most diffuse and focal edema that is not cystoid, it is possible to reliably and repeatably measure the thickness of the retina. Conclusions: For situations where the reflectance of the ILM is compromised, it is difficult presently to provide an absolute thickness measurement. However, in such cases it is still straightforward to determine that an anomaly is present, so there is still diagnostic value in the software's output.

Keywords: retina • macula/fovea • image processing 

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