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B.A. Nassaralla, J.J. Nassaralla; Evaluation of the Prophylactic Use of Mitomycin C to Inhibit Haze Formation After Photorefractive Keratectomy for Residual Myopia Following Radial Keratotomy . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4337.
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Purpose: Evaluation of the prophylactic use of mitomycin C to inhibit haze formation after photorefractive keratectomy for residual myopia following radial keratotomy. Methods: Twenty two eyes of fourteen patients, 5 men and 9 women, with residual myopia after RK were included is this study. The RK procedures were performed from 1988 to 1993 in different eye care centers. Mean age at the time of PRK plus mitomycin C was 39.14 years. All eyes were treated with PRK and a single intraoperative topical application of mitomycin C (0.02%) solution for 2 minutes using a soaked merocel sponge placed over the ablated area. Before PRK, the mean spherical equivalent was –2.73 D (range, –1.50 to –4.00D). The inclusion criteria were low myopia, no central corneal opacity and high risk factors to allow a safe Laser in situ keratomileusis procedure. Refraction, uncorrected visual acuity, best spectacle corrected visual acuity (BSCVA), slit lamp evidence of corneal opacity (haze) and other visible complications, were evaluated over a 12–month follow–up period. Results: Epithelial healing occurred between 4 and 8 days in all eyes. After 12 months, no eye showed haze grade over 1; 3 eyes showed haze grade 1 and 2 eyes, haze grade 0.5. Best spectacle corrected visual acuity was 20/25 or better in twelve eyes. No eye lost any line of the BSCVA as compared to the pre–PRK values. Mean final spherical equivalent achieved was –0.28 D (range, –0.75 to +0.50 D). No adverse effects related to the use of mitomycin C were observed during re–epithelialization or during follow up. Conclusions: PRK with a single intraoperative application of mitomycin C 0.02% was safe and effective in treating residual myopia in patients with undercorrection or regression following RK.
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