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M. Saiki, E. Goto, N. Asano–Kato, S. Suzuki, M. Dogru, K. Tsubota; Kinetic Analysis of Tear Lipid Layer Interference Images in Dry Eye With Allergic Conjunctivitis . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4436.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose:To analyze abnormality of tear film lipid layer in patients with dry eye associated with allergic conjunctivitis (AC) and to assess the efficacy of sodium chromoglycate eye drops using kinetic analysis of tear interference images using DR–1 camera (Kowa, Nagoya, Japan). Methods:Ten patients (4 females and 6 males, age: 31.6±8.3 years) participated in this study. All patients were diagnosed to have AC accompanied with dry eye by slit lamp examination with vital staining and Schirmer test. They were instructed to instill sodium chromoglycate eye drops 4 times per day for 1 week. Tear break up time (BUT), Tear Function Index (TFI), and tear interference images were compared before and after the treatment. For Kinetic Analysis of Tear Interference Images, the methods reported by Goto and Tseng were applied and lipid spread times (LST) were calculated. Results:After the treatment, BUT improved from 2.8 seconds to 6.1 seconds (P<0.05). TFI has improved from 263.7 to 480.0 (P<0.05). DR–1 kinetic analysis showed improvement of the tear lipid spread, and LST was shortened from 1.9 seconds to 1.0 second after the treatment (P<0.05). Conclusions:In the dry eye patients with AC, tear lipid layer abnormality with retarded lipid spread was observed. The abnormal tear conditions improved by instillation of sodium chromoglycate eye drops which were thought to be effective against ocular allergic inflammation resulting in improvement of tear stability.
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