May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Kinetic Analysis of Tear Lipid Layer Interference Images in Dry Eye With Allergic Conjunctivitis
Author Affiliations & Notes
  • M. Saiki
    Dept. of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • E. Goto
    Dept. of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Tokyo Dry Eye Center in Iidabashi Eye Clinic, Tokyo, Japan
  • N. Asano–Kato
    Dept. of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
  • S. Suzuki
    Dept. of Ophthalmology, Tokyo Dental College, Chiba, Japan
  • M. Dogru
    Dept. of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Dept. of Ophthalmology, Tokyo Dental College, Chiba, Japan
  • K. Tsubota
    Dept. of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Dept. of Ophthalmology, Tokyo Dental College, Chiba, Japan
  • Footnotes
    Commercial Relationships  M. Saiki, None; E. Goto, None; N. Asano–Kato, None; S. Suzuki, None; M. Dogru, None; K. Tsubota, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 4436. doi:
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      M. Saiki, E. Goto, N. Asano–Kato, S. Suzuki, M. Dogru, K. Tsubota; Kinetic Analysis of Tear Lipid Layer Interference Images in Dry Eye With Allergic Conjunctivitis . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4436.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose:To analyze abnormality of tear film lipid layer in patients with dry eye associated with allergic conjunctivitis (AC) and to assess the efficacy of sodium chromoglycate eye drops using kinetic analysis of tear interference images using DR–1 camera (Kowa, Nagoya, Japan). Methods:Ten patients (4 females and 6 males, age: 31.6±8.3 years) participated in this study. All patients were diagnosed to have AC accompanied with dry eye by slit lamp examination with vital staining and Schirmer test. They were instructed to instill sodium chromoglycate eye drops 4 times per day for 1 week. Tear break up time (BUT), Tear Function Index (TFI), and tear interference images were compared before and after the treatment. For Kinetic Analysis of Tear Interference Images, the methods reported by Goto and Tseng were applied and lipid spread times (LST) were calculated. Results:After the treatment, BUT improved from 2.8 seconds to 6.1 seconds (P<0.05). TFI has improved from 263.7 to 480.0 (P<0.05). DR–1 kinetic analysis showed improvement of the tear lipid spread, and LST was shortened from 1.9 seconds to 1.0 second after the treatment (P<0.05). Conclusions:In the dry eye patients with AC, tear lipid layer abnormality with retarded lipid spread was observed. The abnormal tear conditions improved by instillation of sodium chromoglycate eye drops which were thought to be effective against ocular allergic inflammation resulting in improvement of tear stability.

Keywords: cornea: tears/tear film/dry eye • conjunctivitis • cornea: clinical science 
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