Intraocular Triamcinolone Acetonide for Postcataract Cyctoid Macular Edema. an OCT and mf–ERG Study

Abstract

Abstract: : Purpose: The purpose of this prospective observational study is to evaluate by means of OCT and mf–ERG the efficacy of intraocular injection of triamcinolone acetonide in patients with cystoid macular edema after uncomplicated cataract surgery. Methods: Eleven eyes of 11 patients (mean age 67.82 years, SD 9.15) were referred with unilateral impairment of visual acuity, due to cystoid macular edema after phacoemulcification. All patients underwent complete ophthalmological examination, including best–corrected visual acuity, tomometry, fundus examination, fluorescein angiography, OCT and mf–ERG recording. All cases were treated with intraocular injection of 4 mg triamcinolone acetonate. Both eyes of each patient were examined at presentation and 1, 3 and 6 months after treatment. Results: At presentation, the mean visual acuity affected eyes was 2.17/10 (standard Snellen chart) (SD 0.18). The mean foveal thickness measured of the by OCT of the affected eyes was 440.54 µm (SD 115.96). The mean retinal response density (RRD) of the affected eyes in area 1 was 4.6 nV/deg² (SD 1.55) and in area 2 5.91 nV/deg² (SD 1.88). Three months after treatment, the mean visual acuity of the affected eyes was 4/10 (SD 0.22). The mean foveal thickness of the affected eyes was 325.5 µm (SD 61.94). The mean RRD of the affected eyes in area 1 was 11 nV/deg² (SD 3.10) and in area 2 8.23 nV/deg² (SD 1.59). Conclusions: Our OCT and mf–ERG findings suggest the efficacy of triamcinolone acetonide as a therapeutic mean of postcataract cystoid macular edema. Although a longer follow–up period and larger sample is needed in order to better evaluate the long–term efficacy of the therapy.

Keywords: cataract • electrophysiology: clinical • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound)