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S.G. Coupland, W.G. Hodge, B.C. Leonard, W.R. Lamba; Structural and Functional Imaging in Cystoid Macular Edema: Optical Coherence Tomography and Multifocal ERG Findings . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4557.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Optical coherence tomography (OCT) has recently become the benchmark for assessing retinal thickness in cystoid macular edema (CME). Retinal thickness measurements are provided in both cross sectional images of the macula as well as two–dimensional topographic retinal thickness maps. Multifocal electroretinography (mERG) is an objective non–invasive technology capable of providing assessment of electroretinal function within the macular region. Multifocal ERG statistical deviation maps provide a topographic distribution of the degree of electroretinal abnormality within the macular region. We chose to compare the correlates of structural imaging (using optical coherence tomography) and functional imaging (using multifocal electroretinography) techniques in a group of patients presenting with cystoid macular edema. Methods: 104 eyes of 60 consecutive patients with CME resulting from uveitis, BVO, CVO and diabetic CSME underwent volumetric OCT assessment and multifocal ERG recording. Mean retinal thickness was determined from OCT within three central rings of 1, 3 and 6 mm diameter. Multifocal ERG statistical deviation maps of response density measurement of the first order kernel were derived from age–appropriate normative data. Mean statistical deviation was determined from the mERG within three central rings of 1, 3 and 6 mm diameter. Results: There was a statistically significant correlation between mean retinal thickness as measured by OCT and mean statistical deviation of the multifocal ERG within the three central rings of 1 mm (p<0.001), 3 mm (p<0.01) and 6 mm (p<0.01) diameter. In a subset of patients treated with intravitreal steroids the multifocal ERG and OCT were measured serially at differing time points. Overall, reduction in multifocal ERG statistical deviation lagged behind the more rapid reduction in retinal thickness as reflected in the OCT. Conclusions: Structural and functional imaging provided by optical coherence tomography and multifocal electroretinography have significant clinical utility in diagnosis and treatment of CME.
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