May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
Colour Contrast Sensitivity as a Predictor of Visual Outcome Following Photodynamic Therapy in Age–Related Macular Degeneration
Author Affiliations & Notes
  • H.L. Cook
    Medical Retina,
    Moorfields Eye Hosp, London, United Kingdom
  • M.M. Neveu
    Electrophysiology Department,
    Moorfields Eye Hosp, London, United Kingdom
  • J.G. Dowler
    Medical Retina,
    Moorfields Eye Hosp, London, United Kingdom
  • G.E. Holder
    Electrophysiology Department,
    Moorfields Eye Hosp, London, United Kingdom
  • A. Tufail
    Medical Retina,
    Moorfields Eye Hosp, London, United Kingdom
  • Footnotes
    Commercial Relationships  H.L. Cook, None; M.M. Neveu, None; J.G. Dowler, Novartis R; G.E. Holder, None; A. Tufail, Novartis R.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 4570. doi:
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      H.L. Cook, M.M. Neveu, J.G. Dowler, G.E. Holder, A. Tufail; Colour Contrast Sensitivity as a Predictor of Visual Outcome Following Photodynamic Therapy in Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4570.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Abstract: : Purpose: To identify prognostic indicators of visual acuity outcome in patients with subfoveal choroidal neovascularisation (CNV) secondary to age–related macular degeneration (ARMD) undergoing photodynamic therapy (PDT). Methods: Thirteen patients with predominately classic subfoveal CNV complicating ARMD underwent a course of photodynamic therapy as per TAP study criteria. Colour contrast sensitivity (CCS) in Protan, Deutan and Tritan axes, pattern electroretinography and multifocal electroretinography were performed at baseline then at 3 monthly intervals over a 2–year follow–up period. Results: Five patients completed 2–year follow–up. Mean baseline LogMAR visual acuity was 0.78 (range 0.6–0.9). Mean 2–year LogMAR visual acuity was 1.0 (range 0.5–1.6). Mean baseline lesion size was 2.85 disc areas (range 0.29–12.58). There was a strong correlation between pre–treatment Protan and Deutan CCS and 2–year LogMAR visual acuity (r=0.994 and r=0.979 respectively). There was a weak correlation between Tritan CCS and 2–year LogMAR visual acuity (r=–0.554). Conclusions: Pre–treatment CCS may be of value as a predictor of final visual acuity in patients undergoing PDT for subfoveal CNV in ARMD.

Keywords: color vision • age-related macular degeneration • photodynamic therapy 
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