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H.L. Cook, M.M. Neveu, J.G. Dowler, G.E. Holder, A. Tufail; Colour Contrast Sensitivity as a Predictor of Visual Outcome Following Photodynamic Therapy in Age–Related Macular Degeneration . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4570.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To identify prognostic indicators of visual acuity outcome in patients with subfoveal choroidal neovascularisation (CNV) secondary to age–related macular degeneration (ARMD) undergoing photodynamic therapy (PDT). Methods: Thirteen patients with predominately classic subfoveal CNV complicating ARMD underwent a course of photodynamic therapy as per TAP study criteria. Colour contrast sensitivity (CCS) in Protan, Deutan and Tritan axes, pattern electroretinography and multifocal electroretinography were performed at baseline then at 3 monthly intervals over a 2–year follow–up period. Results: Five patients completed 2–year follow–up. Mean baseline LogMAR visual acuity was 0.78 (range 0.6–0.9). Mean 2–year LogMAR visual acuity was 1.0 (range 0.5–1.6). Mean baseline lesion size was 2.85 disc areas (range 0.29–12.58). There was a strong correlation between pre–treatment Protan and Deutan CCS and 2–year LogMAR visual acuity (r=0.994 and r=0.979 respectively). There was a weak correlation between Tritan CCS and 2–year LogMAR visual acuity (r=–0.554). Conclusions: Pre–treatment CCS may be of value as a predictor of final visual acuity in patients undergoing PDT for subfoveal CNV in ARMD.
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