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S. Tatlipinar, S. Shah, P.A. Campochiaro, Q. Nguyen; Reproducibility of OCT Measurements in Patients With Neovascular Age–Related Macular Degeneration (NVAMD) . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4791.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: To assess the reproducibility of optical coherence tomography (OCT) measurements in patients with NVAMD. Methods: Ten patients (7 women and 3 men; mean age: 76.9 years) with subfoveal NVAMD in one eye had OCT (StratusOCTTM, Fast Macular Scan) measurements [automated foveal thickness (FT), adjusted FT, automated macular volume (MV), and adjusted MV] by a single experienced operator twice within 5 days. Adjusted measurements are those in which the interface landmarks for measurement are selected by the operator. Bland–Altman method was used to compare results of each parameter between visits to detect differences. Additionally, Bootstrap Comparison of Intraclass Correlation was employed for comparing correlations of automated and adjusted FT, as well as automated and adjusted MV, for variability evaluation. Results: No change occurred in biomicroscopic examination in any of the patients between OCTs. In some patients, poor fixation made accurate scan placement by the OCT operator difficult. The intersession difference was less in adjusted FT (7.8 µ) compared to automated FT (14.7 µ), and was similar in MV measurements (0.072 mm3 and 0.073 mm3 for adjusted and automated MV, respectively). When intraclass correlations (ICC, r = 0.873 and 0.863 for adjusted and automated, respectively) were compared, no statistically significant difference was observed in MV measurements (z–score = –0.150, p= 0.881). However, the difference between adjusted and automated FT ICCs (r = 0.945 and 0.635, respectively) was significant, indicating a higher reproducibility in adjusted FT outcomes (z–score = –2.151, p= 0.031). Conclusions: Measurements of automated or adjusted MV, and adjusted FT are very reproducible. Automated FT measurements have lower reproducibility because OCT software may give false thickness measurements due to irregularities in the retinal pigment epithelium–choriocapillaris complex in patients with NVAMD making interface identification by OCT software unreliable. Use of MV and adjusted thickness values as outcome variables enhances the value of OCT as an assessment tool in patients with NVAMD.
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