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S. Lerner, H. Freile; Intraocular Pressure (IOP) Variations in Different Positions Is Associated With Changes in Anterior Chamber Depth in Patients With Exfoliation Syndrome Glaucoma (GXFS) . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4825.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Fluctuations in IOP have been reported associated with GXFS. The purpose of this study was to analyze the IOP, anterior chamber depth (AC), pachymetry (PA) and axial length (AL) in different positions in GXFS; and to compare them with primary open–angle glaucoma (POAG), exfoliation syndrome without glaucoma (XFS) and normal patients without glaucoma (normals). Methods: 4 groups were evaluated: GXFS (n=15), XFS (n=13), POAG (n=19), and Normals (n=20). IOP was measured with a Perkins tonometer in a seating position, after 30 minutes in a supine position, and then after 30 minutes in a prone position. There were no differences in age among the 3 groups. All patients with glaucoma were under different drugs, excluding pilocarpine. Results: Mean IOP + Standard Deviation was 14.3 (1.8), 13 (1.9) and 14.8 (2) mmHg for the seating, supine and prone positions in the normal group. In the XFS group values were 14 (1), 12.1 (1) and 15.3 (2) mmHg respectively. In the POAG group the values were 17.9 (4.8), 16.4 (4.9) and 18.3 (4.8) mmHg respectively. In the GXFS group the values were 17.6 (2.1), 13.3 (2.1) and 21.7 (1.8) mmHg for the same positions (p< .001). AC results in the GXFS group were 3.07 (0.37), 3.36 (0.36) and 2.78 (0.45) mm for the seating, supine and prone positions (p < 0.001). AC changes in the other groups were not statistically significant. No differences were found in PA and AL when changing positions in the different groups. Conclusions: IOP diminishes in the supine position and rises in the prone position in patients with GXFS. The AC deepens in the supine position and is reduced in the prone position in the GXFS group. No differences were found in normals, XFS and POAG patients. No changes were found in PA and AL in the different groups. Changes in the anterior chamber depth in the different positions may account for the IOP variations in the GXFS group.
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