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F. Ozturk, S. Ermis, S. Yaman; Intraocular Pressure Changes in Different Positions in Pseudoexfoliative Glaucoma and Primary Open–Angle Glaucoma Patients . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4829.
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Purpose: To determine the relationship between postural changes and intraocular pressure (IOP) in pseudoexfoliative glaucoma, primary open–angle glaucoma (POAG) and normal subjects.Methods: Fifteen pseudoexfoliative glaucoma, 10 POAG patients and 10 normal subjects were enrolled. IOP was measured 10 minutes after sitting, supine and prone positions using a Tono Pen (Mentor, USA). All of the glaucoma patients were receiving treatment. Results: The difference in age and gender among groups was statistically insignificant (p>0.05). Mean IOP in sitting, supine and prone positions were 17.3±3.7, 17.3±4.0, 19.3±3.1 mm–Hg in pseudoexfoliative glaucoma group, 17.8±4.0, 20.9±3.6, 21.7±1.7 mm–Hg in POAG group and 14.0±2.5, 15.5±3.5, 16.5±2.6 in normal subjects group respectively. In pseudoexfoliative glaucoma group IOP significantly changed in sitting to prone and supine to prone position alterations (p=0.012 and p=0.003). In POAG group IOP increases were significant when the patients changed from sitting to supine and sitting to prone positions (p=0.005 and p=0.008). In normal subjects the only significant difference was between sitting and prone positions (p=0.014). When the amount of IOP variations were compared among groups statistical signifance was detected in sitting to prone position change between pseudoexfoliative glaucoma and POAG groups (p=0.003). Conclusions: The IOP increase in POAG group from sitting to supine position may be due to change in vascular factors and the increase in supine to prone position change may be due to change in biometric factors. These findings need further investigation.
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