May 2005
Volume 46, Issue 13
Free
ARVO Annual Meeting Abstract  |   May 2005
IOP Measurements During Day and Night Time in Glaucoma Patients and Healthy Controls by Goldmann and Perkins Applanation Tonometry
A.U. Koeller; K. Wozniak; E. Spoerl; A.G. Boehm; L.E. Pillunat
Author Affiliations & Notes
  • A.U. Koeller
    Dept. of Ophthalmology, University of Dresden, Dresden, Germany
  • K. Wozniak
    Dept. of Ophthalmology, University of Dresden, Dresden, Germany
  • E. Spoerl
    Dept. of Ophthalmology, University of Dresden, Dresden, Germany
  • A.G. Boehm
    Dept. of Ophthalmology, University of Dresden, Dresden, Germany
  • L.E. Pillunat
    Dept. of Ophthalmology, University of Dresden, Dresden, Germany
  • Footnotes
    Commercial Relationships  A.U. Koeller, None; K. Wozniak, None; E. Spoerl, None; A.G. Boehm, None; L.E. Pillunat, None.
  • Footnotes
    Support  None.
Investigative Ophthalmology & Visual Science May 2005, Vol.46, 4832. doi:
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      A.U. Koeller, K. Wozniak, E. Spoerl, A.G. Boehm, L.E. Pillunat; IOP Measurements During Day and Night Time in Glaucoma Patients and Healthy Controls by Goldmann and Perkins Applanation Tonometry . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4832.

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Abstract

Abstract: : Purpose: To evaluate IOP levels in glaucoma patients and healthy controls during day and night time while measuring in an upright as well as in a supine position. Methods: In a prospective clinical trial 30 glaucoma patients on topical treatment and 50 healthy controls received IOP measurements every 4 hours for a 24 hour period starting at 8 am. Additionally blood pressure and heart rate were taken and perfusion pressures were calculated. At 12 am IOP was firstly measured in a sitting position and then after 20 min staying in a supine position and at midnight the other way round. At 4am IOP was measured in a supine position all other measurements were performed in a sitting position. Measurements in the sitting position were performed by Goldmann and Perkins tonometry and in a supine position by Perkins tonometry. For statistical analysis ANOVA was used. Results: IOP was 0.96 mmHg (12 pm), 0.94 mmHg (12 am) to 0.7 mmHg (8 pm) lower in Perkins tonometry measurements compared to Goldmann tonometry (P=0.001). There was no difference between the two patient groups. In a supine position IOP measured by Perkins tonometry was higher than in an upright position. At 12 am the difference was 1.9 mmHg ± 2.7 mmHg (P=0.001) in healthy subjects and 1.3 ± 2.7mmHg (P=0.013) in POAG patients. At 12 pm the increase of IOP in the supine position was even more pronounced with 3.2 ± 3.2 mmHg in healthy subjects and 5.5 ± 3.2 mmHg in POAG patients (P=0.001). The blood pressure and the perfusion pressure were lowest at 4 am. There were no differences between the groups (P=0.586). Conclusions: During diurnal IOP measurements in an upright position there were no statistically significant differences in IOP change between both groups. However, in a supine position IOP was significantly higher than in the sitting position and increased more in the glaucoma patients than in healthy controls. This observation might be due to a faulty regulation of the fluid shift in glaucoma patients and might cause progression of glaucomatous damage.

Keywords: intraocular pressure • circadian rhythms 
© 2005, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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