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T. Tai, J.R. Piltz–Seymour, M.D. Mills, A.D. Beck, K.M. Joos, G.–S. Ying, C. Liu; Central Corneal Thickness and Corneal Diameter in Patients With Childhood Glaucomas . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4871.
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Purpose: To determine and compare the central corneal thickness (CCT) and corneal diameter (CD) of patients with childhood aphakic or congenital glaucomas and assess the relationship between CCTand CD in these patients. Methods: Patients from the Scheie Eye Institute, Children’s Hospital of Philadelphia, Vanderbilt Eye Institute and Emory Eye Center who had been diagnosed with childhood aphakic or congenital glaucomas were eligible to participate in this study. Retrospective data on the CCT and CD of these patients were collected when available; patients without usable retrospective data were asked to return to the ophthalmology clinics for CCT measurements using an ultrasonic pachymeter and CD measurements. Patients with corneal edema or central corneal scarring were excluded from the study. The CCT and CD between aphakic and congenital glaucoma patients were compared by t–test with adjustment for the correlation between eyes of same patient. The relationship between CCT and CD was assessed by the Pearson correlation. Results: 16 aphakic eyes of 11 patients (median age = 8.0 years, range = 0.4 – 60 years) and 40 congenital glaucoma eyes of 21 patients (median age = 9.0 years, range = 0.1 – 49.0 years) were included in this study. The mean CCT was 624.5µ (SE= 50.6) in aphakic eyes and 550.7µ (SE= 63.2) in congenital glaucoma eyes; their difference (estimate = 73.8µ, 95% confidence interval = 38.8 – 108.9µ) is significant (p=0.005). There is no significant difference between eyes that have previously undergone surgery verses eyes that have never undergone surgery (p=0.29). The mean of CD in aphakic and congenital glaucoma eyes was 12.5 and 13.7 mm respectively, and their difference is not statistically significant (p=0.13). The correlation between CCT and CD is weak (Pearson correlation coefficient= –0.25, p= 0.054). The associations were maintained even after the adjustment of age, gender and race. Conclusions: Patients with aphakic glaucoma are different from those with congenital glaucoma in CCT, but not in CD. Weak but borderline significant correlation was found between CCT and CD.
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