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L.E. Fernandez de Castro, H.P. Sandoval, D.T. Vroman, K.D. Solomon; Comparison of 5 Fluoroquinolones in Corneal Wound Healing Rate in An Animal Model . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4875.
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© ARVO (1962-2015); The Authors (2016-present)
Purpose: Effects of fluoroquinolones, in the rate of corneal wound healing after anterior keratectomy. Methods: Female NZW rabbits were randomly divided into 6groups n=6/group after 8mm central–AK performed OU. Treatment qid for 5days with BSS, 0.3%ciprofloxacin, 0.5%levofloxacin, 0.5%moxifloxacin, 0.3%gatifloxacin, and 0.3%ofloxacin. The healing rate was assessed by slit–lamp microphotography. Three rabbits per/group were sacrificed at 48, and at 96hrs/post–AK. Corneas used for immunohistochemical study. Results:Epithelial healing rate µm/h for Ofloxacin 39.9, BSS 31.6, gatifloxacin 29.8, Moxifloxacin 28.7, levofloxacin 26.9, and ciprofloxacin 23.6. There is evidence of suppression in collagen IV expression in the migrating corneal epithelial cells in the moxifloxacin and levofloxacin group at day 3. No difference in collagen IV expression among the groups at day 5. Conclusions: Treatment with ciprofloxacin, ofloxacin, BSS, and gatifloxacin, did not delay corneal epithelial healing, nor decrease collagen type IV expression in the early phases of wound healing. Future quantitative analysis of Collagen IV expression using Western blot is required. Additionally, is important to further investigate the clinical implications from this study.
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