Purchase this article with an account.
P. Setabutr, M.S. Sami, M.O. Folterman, A.Z. Chuang, R.W. Yee; A Comparison of Epithelial Healing Rates With Topical Moxifloxacin and Gatifloxacin After Bilateral Photorefractive Keratectomy (PRK) . Invest. Ophthalmol. Vis. Sci. 2005;46(13):4878.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
Purpose: To compare the effect of topical moxifloxacin (VigamoxTM) and gatifloxacin (ZymarTM) on corneal wound healing in patients undergoing bilateral PRK. Methods: Twenty–one patients with moderate myopia or hyperopia, ranging from 23 to 71 years of age, were randomized into two groups: moxifloxacin (n = 10) and gatifloxacin (n = 11). After standardized bilateral PRK, antibiotics were administered in both eyes immediately and then every 6 hours until complete wound healing occurred. Slit–lamp fluorescein pictures were taken of each eye immediately after surgery and on postoperative days until complete wound healing occurred. Surface area of the corneal defect was measured using NIH software (Image J). Results: The data analysis showed no difference in the time of wound closure (P = 0.20) between the two agents. The healing rate was 0.7 mm2/hour ± 0.17(mean ± SD) with moxifloxacin, and 0.7 mm2/hour ± 0.21 with gatifloxacin, demonstrating no significant difference (P = 0.30). There were no differences in the haze grading (P = 0.09) or in postoperative uncorrected visual acuity (P > 0.16) at one month. Conclusions: There were no significant differences in wound healing, haze or visual acuity between the two fourth generation fluoroquinolones, VigamoxTM and ZymarTM following PRK.
This PDF is available to Subscribers Only