Abstract:
To establish the fluorquinolones MIC 90 values for ocular Gram negative bacilli and Gram positive cocci in São Paulo – Brazil.
We carried out in vitro antibiotic susceptibility test (E–test) and determined the MIC 90 values for gatifloxacin (GAT), moxifloxacin (MOX), ciprofloxacin (CIP) and ofloxacin (OFLOX) for ocular Gram negative bacilli and Gram positive cocci strains. Selected isolated pathogens from keratitis, conjunctivitis and endophthalmitis were tested.
Ciprofloxacin MIC
90 is lower for some Gram negative
bacilli, while Moxifloxacin and Gatifloxacin MIC
90 values was
lower for all Gram positive cocci. Based on MIC values results,
the fourth generation fluorquinolones may offer some advantages
over the second generation. Our results in a specific geographical
area are comparable with the latest published data.
Keywords: antibiotics/antifungals/antiparasitics • bacterial disease • drug toxicity/drug effects